{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:06:39Z","timestamp":1784545599452,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain\u2010enriched \u03b2\u2010synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a tertiary\u2010center cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009306), CSF \u03b2\u2010synuclein was measured. Cognitively unimpaired (CU), AD\u2010MCI, AD dementia (ADD), and non\u2010AD (FTD, PD, DLB, others) groups were included. ANCOVA compared groups (age\/sex adjusted); ROC assessed diagnostic performance. Multivariable regression examined 2\u2010year MMSE decline associations. Voxel\u2010wise interaction models evaluated \u03b2\u2010synuclein\u2013gray matter volume (GMV) relationships.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CSF \u03b2\u2010synuclein differed across groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with highest levels observed in AD\u2010MCI and lower levels in ADD. AD\u2010MCI levels exceeded CU\/ADD. AD\u2010MCI versus CU AUC was 0.874. Baseline \u03b2\u2010synuclein predicted greater MMSE decline in AD\u2010MCI (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.72,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and ADD (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.47,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). Voxel\u2010wise analyses revealed stage\u2010dependent \u03b2\u2010synuclein\u2013GMV reversals in precentral and temporoparietal regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CSF \u03b2\u2010synuclein shows a stage\u2010dependent pattern across the AD continuum, predicts cognitive decline, and dynamic structural coupling. It supports \u03b2\u2010synuclein as a relevant synaptic biomarker in AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70494","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:38:53Z","timestamp":1784543933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stage\u2010Dependent \u03b2\u2010Synuclein Links\n                    <scp>MRI<\/scp>\n                    and Cognitive Decline in Alzheimer's Disease"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7896-3681","authenticated-orcid":false,"given":"Ula\u015f","family":"Ay","sequence":"first","affiliation":[{"name":"Neuroimaging Unit, Hulusi Beh\u00e7et Life Sciences Research Laboratory Istanbul University  Istanbul Turkey"},{"name":"Department of Physiology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Alaylioglu","sequence":"additional","affiliation":[{"name":"Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdi","family":"Sahin","sequence":"additional","affiliation":[{"name":"Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanem Sultan Yoruk","family":"Oner","sequence":"additional","affiliation":[{"name":"Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulce","family":"Iskan","sequence":"additional","affiliation":[{"name":"Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulce Cosku Yilmaz","family":"Cakan","sequence":"additional","affiliation":[{"name":"Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gozde","family":"Kizilates\u2010Evin","sequence":"additional","affiliation":[{"name":"Neuroimaging Unit, Hulusi Beh\u00e7et Life Sciences Research Laboratory Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Hari","sequence":"additional","affiliation":[{"name":"Neuroimaging Unit, Hulusi Beh\u00e7et Life Sciences Research Laboratory Istanbul University  Istanbul Turkey"},{"name":"Department of Physiology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1956-575X","authenticated-orcid":false,"given":"Elif","family":"Kurt","sequence":"additional","affiliation":[{"name":"Neuroimaging Unit, Hulusi Beh\u00e7et Life Sciences Research Laboratory Istanbul University  Istanbul Turkey"},{"name":"Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdinc","family":"Dursun","sequence":"additional","affiliation":[{"name":"Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basar","family":"Bilgic","sequence":"additional","affiliation":[{"name":"Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasmet","family":"Hanagasi","sequence":"additional","affiliation":[{"name":"Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Gurvit","sequence":"additional","affiliation":[{"name":"Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Demiralp","sequence":"additional","affiliation":[{"name":"Neuroimaging Unit, Hulusi Beh\u00e7et Life Sciences Research Laboratory Istanbul University  Istanbul Turkey"},{"name":"Department of Physiology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Gezen\u2010Ak","sequence":"additional","affiliation":[{"name":"Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0667-2329","authenticated-orcid":false,"given":"Bedia","family":"Samanci","sequence":"additional","affiliation":[{"name":"Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological Stageing of Alzheimer\u2010Related Changes","volume":"82","author":"Braak H.","year":"1991","journal-title":"Acta Neuropathologica"},{"issue":"10284","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's Disease","volume":"397","author":"Scheltens P.","year":"2021","journal-title":"Lancet"},{"issue":"8","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised Criteria for Diagnosis and Staging of Alzheimer's Disease: Alzheimer's Association Workgroup","volume":"20","author":"Jack C. R.","year":"2024","journal-title":"Alzheimer's & Dementia"},{"issue":"1","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41582-022-00749-z","article-title":"Synaptic Degeneration in Alzheimer Disease","volume":"19","author":"Tzioras M.","year":"2023","journal-title":"Nature Reviews. Neurology"},{"issue":"4","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical Basis of Cognitive Alterations in Alzheimer's Disease: Synapse Loss Is the Major Correlate of Cognitive Impairment","volume":"30","author":"Terry R. D.","year":"1991","journal-title":"Annals of Neurology"},{"issue":"4","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.bcp.2014.01.015","article-title":"Pathogenesis of Synaptic Degeneration in Alzheimer's Disease and Lewy Body Disease","volume":"88","author":"Overk C. R.","year":"2014","journal-title":"Biochemical Pharmacology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neuropharm.2013.10.018","article-title":"Synaptic Gene Dysregulation Within Hippocampal CA1 Pyramidal Neurons in Mild Cognitive Impairment","volume":"79","author":"Counts S. E.","year":"2014","journal-title":"Neuropharmacology"},{"issue":"10","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.neurobiolaging.2005.09.012","article-title":"Hippocampal Synaptic Loss in Early Alzheimer's Disease and Mild Cognitive Impairment","volume":"27","author":"Scheff S. W.","year":"2006","journal-title":"Neurobiology of Aging"},{"issue":"9","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/s41582-021-00520-w","article-title":"Developing the ATX(N) Classification for Use Across the Alzheimer Disease Continuum","volume":"17","author":"Hampel H.","year":"2021","journal-title":"Nature Reviews. Neurology"},{"issue":"1","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s12035-025-05461-9","article-title":"The CSF Levels of Mitochondrial Phosphoenolpyruvate Carboxykinase 2 as a Novel Biomarker in Alzheimer's Disease","volume":"63","author":"Ilhan N.","year":"2025","journal-title":"Molecular Neurobiology"},{"issue":"7","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70162","article-title":"Unravelling the Plasma Proteome: Pioneering Biomarkers for Differential Dementia Diagnosis","volume":"21","author":"Gezegen H.","year":"2025","journal-title":"Alzheimer's & Dementia: The Journal of the Alzheimer's Association"},{"issue":"2","key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1177\/13872877251329540","article-title":"Cerebrospinal Fluid HSP90AA1, HSPA4, and STUB1\/CHIP Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Frontotemporal Dementia","volume":"105","author":"Sordu P.","year":"2025","journal-title":"Journal of Alzheimer's Disease"},{"issue":"1","key":"e_1_2_11_14_1","article-title":"The Synucleins","volume":"3","author":"George J. M.","year":"2002","journal-title":"Genome Biology"},{"issue":"1","key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3390\/biom12010142","article-title":"Beta\u2010Synuclein: An Enigmatic Protein With Diverse Functionality","volume":"12","author":"Hayashi J.","year":"2022","journal-title":"Biomolecules"},{"issue":"12","key":"e_1_2_11_16_1","first-page":"1144","article-title":"Serum Level Changes of the Synaptic Marker Beta\u2010Synuclein in Alzheimer's Disease Continuum and Other Dementias","volume":"96","author":"Barba L.","year":"2025","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"12","key":"e_1_2_11_17_1","first-page":"1154","article-title":"Elevated Serum Beta\u2010Synuclein Predicts Cognitive Decline and Progression to Dementia","volume":"96","author":"Kong N.","year":"2025","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"1","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/jnnp-2022-329124","article-title":"Cerebrospinal Fluid Beta\u2010Synuclein as a Synaptic Biomarker for Preclinical Alzheimer's Disease","volume":"94","author":"Barba L.","year":"2023","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"10","key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1074\/mcp.M116.059915","article-title":"Alpha\u2010, Beta\u2010, and Gamma\u2010Synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer's and Creutzfeldt\u2010Jakob Disease but no Alteration in Synucleinopathies","volume":"15","author":"Oeckl P.","year":"2016","journal-title":"Molecular & Cellular Proteomics"},{"issue":"3","key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1021\/acs.jproteome.9b00824","article-title":"Targeted Mass Spectrometry Suggests Beta\u2010Synuclein as Synaptic Blood Marker in Alzheimer's Disease","volume":"19","author":"Oeckl P.","year":"2020","journal-title":"Journal of Proteome Research"},{"issue":"4","key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/jnnp-2020-324306","article-title":"Beta\u2010Synuclein in Cerebrospinal Fluid as an Early Diagnostic Marker of Alzheimer's Disease","volume":"92","author":"Halbgebauer S.","year":"2021","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"1","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-025-01716-8","article-title":"Novel CSF Beta\u2010Synuclein\u2010Specific Assays Signal Early Synaptic Degeneration in Alzheimer's Disease","volume":"17","author":"Bayoumy S.","year":"2025","journal-title":"Alzheimer's Research & Therapy"},{"issue":"4","key":"e_1_2_11_23_1","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70146","article-title":"Early Increase of the Synaptic Blood Marker Beta\u2010Synuclein in Asymptomatic Autosomal Dominant Alzheimer's Disease","volume":"21","author":"Oeckl P.","year":"2025","journal-title":"Alzheimer's & Dementia"},{"issue":"11","key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"5095","DOI":"10.1002\/alz.13103","article-title":"Higher Plasma Beta\u2010Synuclein Indicates Early Synaptic Degeneration in Alzheimer's Disease","volume":"19","author":"Oeckl P.","year":"2023","journal-title":"Alzheimer's & Dementia"},{"issue":"1","key":"e_1_2_11_25_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-022-01125-1","article-title":"Beta\u2010Synuclein as a Candidate Blood Biomarker for Synaptic Degeneration in Alzheimer's Disease","volume":"14","author":"Mohaupt P.","year":"2022","journal-title":"Alzheimer's Research & Therapy"},{"issue":"5","key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/alz.12809","article-title":"Cerebrospinal Fluid Biomarker Panel of Synaptic Dysfunction in Alzheimer's Disease and Other Neurodegenerative Disorders","volume":"19","author":"Nilsson J.","year":"2023","journal-title":"Alzheimer's & Dementia"},{"issue":"4","key":"e_1_2_11_27_1","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/alz.12790","article-title":"Relationship of Serum Beta\u2010Synuclein With Blood Biomarkers and Brain Atrophy","volume":"19","author":"Oeckl P.","year":"2023","journal-title":"Alzheimer's & Dementia"},{"key":"e_1_2_11_28_1","unstructured":"Association AP \u201cDiagnostic and Statistical Manual of Mental Disorders (DSM\u20105) \u201d(2013)."},{"issue":"1","key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/ageing\/afaa228","article-title":"Mild Cognitive Impairment: The Manchester Consensus","volume":"50","author":"Dunne R. A.","year":"2021","journal-title":"Age and Ageing"},{"issue":"9","key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of Revised Diagnostic Criteria for the Behavioural Variant of Frontotemporal Dementia","volume":"134","author":"Rascovsky K.","year":"2011","journal-title":"Brain"},{"issue":"11","key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of Primary Progressive Aphasia and Its Variants","volume":"76","author":"Gorno\u2010Tempini M. L.","year":"2011","journal-title":"Neurology"},{"issue":"12","key":"e_1_2_11_32_1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS Clinical Diagnostic Criteria for Parkinson's Disease","volume":"30","author":"Postuma R. B.","year":"2015","journal-title":"Movement Disorders"},{"issue":"1","key":"e_1_2_11_33_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and Management of Dementia With Lewy Bodies: Fourth Consensus Report of the DLB Consortium","volume":"89","author":"McKeith I. G.","year":"2017","journal-title":"Neurology"},{"issue":"5","key":"e_1_2_11_34_1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","article-title":"Criteria for the Diagnosis of Corticobasal Degeneration","volume":"80","author":"Armstrong M. J.","year":"2013","journal-title":"Neurology"},{"issue":"6","key":"e_1_2_11_35_1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mds.26987","article-title":"Clinical Diagnosis of Progressive Supranuclear Palsy: The Movement Disorder Society Criteria","volume":"32","author":"Hoglinger G. U.","year":"2017","journal-title":"Movement Disorders"},{"key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"giae049","DOI":"10.1093\/gigascience\/giae049","article-title":"The Alzheimer's Disease Neuroimaging I. CAT: A Computational Anatomy Toolbox for the Analysis of Structural MRI Data","volume":"13","author":"Gaser C.","year":"2024","journal-title":"GigaScience"},{"issue":"12","key":"e_1_2_11_37_1","first-page":"1131","article-title":"Beta\u2010Synuclein: A Dynamic Biomarker and Modulator in Neurodegenerative Dementia","volume":"96","author":"Bucci M.","year":"2025","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"420","key":"e_1_2_11_38_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroscience.2018.11.038","article-title":"A Novel ELISA for the Measurement of Cerebrospinal Fluid SNAP\u201025 in Patients With Alzheimer's Disease","volume":"10","author":"Ohrfelt A.","year":"2019","journal-title":"Neuroscience"},{"issue":"1","key":"e_1_2_11_39_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-53086-8","article-title":"Beta\u2010Synuclein Regulates the Phase Transitions and Amyloid Conversion of Alpha\u2010Synuclein","volume":"15","author":"Li X.","year":"2024","journal-title":"Nature Communications"},{"issue":"14","key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"e1434","DOI":"10.1212\/WNL.0000000000200002","article-title":"Blood Beta\u2010Synuclein and Neurofilament Light Chain During the Course of Prion Disease","volume":"98","author":"Halbgebauer S.","year":"2022","journal-title":"Neurology"},{"issue":"10","key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/acn3.51873","article-title":"High Diagnostic Performance of Plasma and Cerebrospinal Fluid Beta\u2010Synuclein for Sporadic Creutzfeldt\u2010Jakob Disease","volume":"10","author":"Abu\u2010Rumeileh S.","year":"2023","journal-title":"Annals of Clinical Translational Neurology"},{"issue":"11","key":"e_1_2_11_42_1","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1002\/alz.13046","article-title":"Blood Beta\u2010Synuclein Is Related to Amyloid PET Positivity in Memory Clinic Patients","volume":"19","author":"Oeckl P.","year":"2023","journal-title":"Alzheimer's & Dementia"},{"issue":"12","key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A Beta\u2010Deposition in the Human Brain and Its Relevance for the Development of AD","volume":"58","author":"Thal D. R.","year":"2002","journal-title":"Neurology"},{"issue":"4","key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer Disease\u2010Associated Neurofibrillary Pathology Using Paraffin Sections and Immunocytochemistry","volume":"112","author":"Braak H.","year":"2006","journal-title":"Acta Neuropathologica"},{"issue":"1","key":"e_1_2_11_45_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s41016-021-00241-5","article-title":"Proteomic Analysis of Human Frontal and Temporal Cortex Using iTRAQ\u2010Based 2D LC\u2010MS\/MS","volume":"7","author":"Xu L.","year":"2021","journal-title":"Chinese Neurosurgical Journal"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70494","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.70494","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:38:59Z","timestamp":1784543939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.70494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":44,"alternative-id":["10.1002\/acn3.70494"],"URL":"https:\/\/doi.org\/10.1002\/acn3.70494","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]},"assertion":[{"value":"2026-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"acn3.70494"}}