{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:05:36Z","timestamp":1784793936806,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Choroid plexus volume (CPV) has been proposed as a neuro\u2010immunological marker of multiple sclerosis (MS), but its relevance in myelin oligodendrocyte glycoprotein antibody\u2013associated disease (MOGAD) remains uncertain. We analyzed CPV in 43 individuals with MOGAD, 48 with MS, and 44 healthy controls using a Bayesian Gaussian mixture modeling applied to 3D\u2010T1\u2010weighted\u2010MRI. Total intracranial volume\u2010normalized CPV did not differ between MOGAD and healthy controls, whereas the MS demonstrated significantly higher values than both groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and showed associations with clinical disability. These findings suggest relative preservation of CPV in MOGAD and support a closer association of CPV enlargement with disease\u2010related structural changes in MS than in MOGAD.\n                  <\/jats:p>","DOI":"10.1002\/acn3.70495","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T07:34:33Z","timestamp":1784792073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Analysis of Choroid Plexus Volume Between\n                    <scp>MOG<\/scp>\n                    Antibody Associated Disease and Multiple Sclerosis"],"prefix":"10.1002","author":[{"given":"Jae\u2010Won","family":"Hyun","sequence":"first","affiliation":[{"name":"Department of Neurology Research Institute and Hospital of National Cancer Center  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun G.","family":"Hong","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Research Institute and Hospital of National Cancer Center  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Research Institute and Hospital of National Cancer Center  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-8419","authenticated-orcid":false,"given":"Ho Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Research Institute and Hospital of National Cancer Center  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jneuroim.2008.04.035","article-title":"Involvement of the Choroid Plexus in Multiple Sclerosis Autoimmune Inflammation: A Neuropathological Study","volume":"199","author":"Vercellino M.","year":"2008","journal-title":"Journal of Neuroimmunology"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000001147","article-title":"Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder: A Retrospective, Cross\u2010Sectional Analysis","volume":"9","author":"Muller J.","year":"2022","journal-title":"Neurology(R) Neuroimmunology & Neuroinflammation"},{"issue":"1","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1148\/radiol.2021204426","article-title":"Choroid Plexus Enlargement in Inflammatory Multiple Sclerosis: 3.0\u2010T MRI and Translocator Protein PET Evaluation","volume":"301","author":"Ricigliano V. A. G.","year":"2021","journal-title":"Radiology"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S1474-4422(22)00431-8","article-title":"Diagnosis of Myelin Oligodendrocyte Glycoprotein Antibody\u2010Associated Disease: International MOGAD Panel Proposed Criteria","volume":"22","author":"Banwell B.","year":"2023","journal-title":"Lancet Neurology"},{"issue":"2","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of Multiple Sclerosis: 2017 Revisions of the McDonald Criteria","volume":"17","author":"Thompson A. J.","year":"2018","journal-title":"Lancet Neurology"},{"issue":"4","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3233\/JAD-190706","article-title":"Improving Choroid Plexus Segmentation in the Healthy and Diseased Brain: Relevance for Tau\u2010PET Imaging in Dementia","volume":"74","author":"Tadayon E.","year":"2020","journal-title":"Journal of Alzheimer's Disease"},{"issue":"3","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaf239","article-title":"The Temporal Dynamics and Clinical Relevance of Choroid Plexus Measures in Multiple Sclerosis","volume":"7","author":"Meo E. D.","year":"2025","journal-title":"Brain Communications"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"e911","DOI":"10.1212\/WNL.0000000000201608","article-title":"Association of Choroid Plexus Inflammation on MRI With Clinical Disability Progression Over 5\u2009Years in Patients With Multiple Sclerosis","volume":"100","author":"Bergsland N.","year":"2023","journal-title":"Neurology"},{"issue":"6","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200026","article-title":"Imaging Characteristics of Choroid Plexuses in Presymptomatic Multiple Sclerosis: A Retrospective Study","volume":"9","author":"Ricigliano V. A. G.","year":"2022","journal-title":"Neurology(R) Neuroimmunology & Neuroinflammation"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200319","article-title":"Choroid Plexus Volume in Pediatric\u2010Onset Multiple Sclerosis","volume":"11","author":"Grasso E. A.","year":"2024","journal-title":"Neurology Neuroimmunology & Neuroinflammation"},{"issue":"2","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ana.25150","article-title":"Thalamic Atrophy in Multiple Sclerosis: A Magnetic Resonance Imaging Marker of Neurodegeneration Throughout Disease","volume":"83","author":"Azevedo C. J.","year":"2018","journal-title":"Annals of Neurology"},{"key":"e_1_2_9_13_1","article-title":"Rarity of Silent Progression: PIRA and RAW in Myelin Oligodendrocyte Glycoprotein Antibody\u2010Associated Disease","volume":"13","author":"Kim K. H.","year":"2026","journal-title":"Multiple Sclerosis"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.70495","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T07:34:35Z","timestamp":1784792075000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.70495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":12,"alternative-id":["10.1002\/acn3.70495"],"URL":"https:\/\/doi.org\/10.1002\/acn3.70495","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"2026-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"acn3.70495"}}