{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:01Z","timestamp":1787383381365,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI24\/00859"],"award-info":[{"award-number":["PI24\/00859"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence and clinical characteristics of patients with \u201clow\u2010positive\u201d (LP) MOG\u2010IgG (titres 1:160\u20131:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From the Barcelona CIS inception cohort, we included adult patients with serum collected \u2264\u20096\u2009months from the FDE. MOG\u2010IgG was assessed by a cell\u2010based assay with flow cytometry (CBA\u2010FC). Demographic, clinical, and paraclinical data were compared among seronegative, LP, and \u201cclear\u2010positive\u201d (CP; \u2265\u20091:640) patients. Supporting MOGAD features and final diagnoses were retrospectively reviewed in seropositive cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 613 patients, 42 (6.9%) were MOG\u2010IgG positive (CP\u2009=\u200917; LP\u2009=\u200925). LP patients were indistinguishable from seronegative patients but differed from CP patients, who more frequently had optic neuritis, lacked cerebrospinal fluid\u2010oligoclonal bands, and were less likely to meet the McDonald criteria (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). At the last follow\u2010up, 64% of LP versus 18% of CP patients were diagnosed with MS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Only one LP patient fulfilled MOGAD criteria, compared with 14 CP patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Lowering the CBA\u2010FC positivity threshold to \u2265\u20091:160 had limited diagnostic yield in this MS\u2010predominant cohort, as most LP cases were ultimately diagnosed with MS. These findings support cautious interpretation of LP MOG\u2010IgG results in this clinical setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70496","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:26:48Z","timestamp":1787380008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u201cLow\u2010Positive\u201d\n                    <scp>MOG<\/scp>\n                    \u2010\n                    <scp>IgG<\/scp>\n                    Cases Among Adults With a First Event Suggestive of Multiple Sclerosis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5443-1434","authenticated-orcid":false,"given":"Javier","family":"Villacieros\u2010\u00c1lvarez","sequence":"first","affiliation":[{"name":"Neurology Department and Centre D'esclerosi M\u00faltiple de Catalunya (Cemcat) Hospital Universitari Vall D'hebron, Vall D'hebron Institut de Recerca.  Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Neurology Department, Unidad de Neuroinmunolog\u00eda Hospital Universitari Germans Trias i Pujol.  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Espejo","sequence":"additional","affiliation":[{"name":"Neurology Department and Centre D'esclerosi M\u00faltiple de Catalunya (Cemcat) Hospital Universitari Vall D'hebron, Vall D'hebron Institut de Recerca.  Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Arrambide","sequence":"additional","affiliation":[{"name":"Neurology Department and Centre D'esclerosi M\u00faltiple de Catalunya (Cemcat) Hospital Universitari Vall D'hebron, Vall D'hebron Institut de Recerca.  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