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RIPC<\/jats:styled-content> was initiated by 5\u2010min cuff inflation\/deflation cycles of the target limb(s) for 5\u201310\u00a0bouts. Vital signs, skin integrity, brain MRI<\/jats:styled-content>, and serum levels of cardiac enzymes (myoglobin, creatine kinase [CK<\/jats:styled-content>], CK<\/jats:styled-content>\u2010muscle\/brain [CK<\/jats:styled-content>\u2010MB<\/jats:styled-content>]), one inflammatory marker (high\u2010sensitivity C\u2010reactive protein [hsCRP<\/jats:styled-content>], and one endothelial injury marker (von Willebrand factor [vWF<\/jats:styled-content>]) were assessed. Spetzler scores were used to assess neurological function.<\/jats:p><\/jats:sec>Results<\/jats:title>No significant differences in vital signs or local skin integrity were found. Short\u2010term RIPC<\/jats:styled-content> did not reduce infarct volume under any condition at the 24th hour after stroke. However, neurological function improved in multi\u2010limb RIPC<\/jats:styled-content> compared with sham and single\u2010limb RIPC<\/jats:styled-content> at the 30th day follow\u2010up after stroke. Myoglobin, CK<\/jats:styled-content>, and CK<\/jats:styled-content>\u2010MB<\/jats:styled-content> levels were reduced after multi\u2010limb RIPC<\/jats:styled-content>, regardless of the number of bouts. Moreover, multi\u2010limb RIPC<\/jats:styled-content> produced a greater diminution in CK<\/jats:styled-content>\u2010MB<\/jats:styled-content> levels, whereas two\u2010limb RIPC<\/jats:styled-content> was more effective in reducing serum CK<\/jats:styled-content> levels at the 24th hour after stroke. hsCRP<\/jats:styled-content> increased after 5\u00a0bouts of multi\u2010limb RIPC<\/jats:styled-content> before decreasing below baseline and single\u2010limb RIPC<\/jats:styled-content> levels. Serum vWF<\/jats:styled-content> was decreased at later time points after RIPC<\/jats:styled-content> in all RIPC<\/jats:styled-content> groups.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Stroke monkeys in hyperacute stage may benefit from short\u2010term RIPC<\/jats:styled-content>; however, whether this intervention can be translated into clinical use in patients with acute ischemic stroke warrants further study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.705","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T10:53:12Z","timestamp":1547549592000},"page":"310-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Short\u2010term remote ischemic conditioning may protect monkeys after ischemic stroke"],"prefix":"10.1002","volume":"6","author":[{"given":"Linlin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical 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