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Herein, we describe three men with early\u2010stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher\u2010order visual dysfunction and posterior interhemispheric disconnection signs, including visual\u2010field\u2010dependent reading or naming deficits and dichotic listening abnormalities. Diffusion tensor imaging showed preferential involvement of posterior callosal and visual stream\u2010related white\u2010matter pathways. These findings define a posterior disconnection phenotype of adult\u2010onset cerebral adrenoleukodystrophy and provide a clinically useful framework for early recognition and timely therapeutic consideration of this treatable leukodystrophy.<\/jats:p>","DOI":"10.1002\/acn3.70501","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:26:42Z","timestamp":1786944402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Posterior Disconnection Syndrome in Early\u2010Stage Adult\u2010Onset Cerebral Adrenoleukodystrophy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-6971","authenticated-orcid":false,"given":"Kazuto","family":"Katsuse","sequence":"first","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Behavioral Neurology and Cognitive Neuroscience Tohoku University 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