{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:30:41Z","timestamp":1786537841636,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Peak\u2010width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging\u2013analysis along the perivascular space (DTI\u2010ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD). We evaluated whether these biomarkers differ between AD participants with and without concomitant cerebral amyloid angiopathy (CAA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 50 AD participants with mild cognitive impairment\/mild dementia, and intermediate to high AD neuropathologic change at autopsy. AD was categorized as AD with CAA and AD without CAA based on CAA neuropathology. We evaluated global and regional (frontal, parietal, temporal and occipital) PSMD; left, right and mean DTI\u2010ALPS indices and their association with clinical measures [Clinical dementia rating sum\u2010of\u2010boxes (CDR\u2010SB) from CDR Dementia Staging Instrument, mini mental state examination (MMSE), cognitive composites: memory, processing speed, executive function, and language].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      AD participants with CAA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917) had higher global [4.02\u2009\u00b1\u20091.44 (mean\u2009\u00b1\u2009SD\u2009\u00d7\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      \u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s) vs. 3.12\u2009\u00b1\u20090.91,\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.80, 95% CI (\u22121.42, \u22120.18),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012] and occipital PSMD [4.02\u2009\u00b1\u20091.10 vs. 3.00\u2009\u00b1\u20091.08,\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.88, 95% CI (\u22121.51, \u22120.26),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026] than those without CAA. No PSMD metric was associated with any clinical measure. However, imaging\u2010by\u2010group interactions showed global PSMD associated with language [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.89, 95% CI (\u22121.53, \u22120.26),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027] and parietal PSMD with language [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.05, 95% CI (\u22121.74, \u22120.36),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014] and memory [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.83, 95% CI (\u22121.38, \u22120.28),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015]. DTI\u2010ALPS indices did not differ by group. Higher mean and right DTI\u2010ALPS indices were associated with preserved language function [mean:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20099.33, 95% CI (2.05, 16.62),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036; right:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20097.75, 95% CI (1.54, 13.95),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043] without imaging\u2010by\u2010group interactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Global and occipital PSMD may help identify AD participants with concomitant CAA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70506","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:41:01Z","timestamp":1786534861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy"],"prefix":"10.1002","author":[{"given":"Debina","family":"Laishram","sequence":"first","affiliation":[{"name":"Department of Neurology Penn State Health Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology Penn State Health Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangam","family":"Kanekar","sequence":"additional","affiliation":[{"name":"Department of Radiology Penn State Health Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandakumar","family":"Nagaraja","sequence":"additional","affiliation":[{"name":"Department of Neurology Penn State Health Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"733","article-title":"Update on the Biological Diagnosis of Alzheimer's Disease and Relevance for New AD Therapeutics and Neuropsychology","volume":"36","author":"Jack C.","year":"2022","journal-title":"Clinical Neuropsychologist"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward Defining the Preclinical Stages of Alzheimer's Disease: Recommendations From the National Institute on Aging\u2010Alzheimer's Association Workgroups on Diagnostic Guidelines for Alzheimer's Disease","volume":"7","author":"Sperling R. 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