{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:21:04Z","timestamp":1786116064506,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to identify the proportion of individuals with a confirmed diagnosis of childhood absence epilepsy (CAE) or juvenile absence epilepsy (JAE) who show a negative routine EEG (rEEG), and to determine the main factors associated with this finding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Individuals with CAE or JAE underwent both an rEEG and a 24\u2010h ambulatory EEG (24\u2010h\u2010aEEG). Participants were classified as \u2018rEEG positive\u2019 if generalised spike\u2013wave discharges (GSWs) and\/or typical absences (TAs) were observed, and as \u2018rEEG negative\u2019 if no such features were detected. 24\u2010h\u2010aEEG recordings served as the ground truth to confirm the diagnosis in cases with a negative rEEG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010two individuals [40\/82 (48.8%) females; mean age 12.5\u2009\u00b1\u20095.6\u2009years] were included, of whom 39\/82 (47.6%) were not receiving anti\u2010seizure medications (ASMs) at the time of the EEG. Overall, 31\/82 (37.8%) had a negative rEEG, including 10\/39 (25.6%) in the cohort of ASM\u2010na\u00efve individuals. Compared with rEEG\u2010positive participants, those in the rEEG\u2010negative group had a later age at epilepsy onset (12.1\u2009\u00b1\u20094.5\u2009years;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and were older at the time of EEG (16.5\u2009\u00b1\u20095.3\u2009years;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Older age at EEG emerged as significantly associated with a negative rEEG (OR\u2009=\u20091.23; 95% CI\u2009=\u20091.03\u20131.46;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), independent of age at onset, epilepsy syndrome (CAE or JAE) and ASM exposure. Sensitivity analyses confirmed the association between older age and rEEG negativity across all cohorts: ASM\u2010na\u00efve individuals (OR\u2009=\u20091.41; 95% CI\u2009=\u20091.12\u20131.78), CAE (OR\u2009=\u20091.27; 95% CI\u2009=\u20091.02\u20131.58), and JAE (OR\u2009=\u20091.36; 95% CI 1.09\u20131.69) groups. Youden's exploratory analysis identified \u2265\u200914\u2009years as the optimal threshold for predicting a rEEG negative.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Age significantly reduces the diagnostic yield of rEEG in CAE and JAE, regardless of ASM treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70507","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T07:15:45Z","timestamp":1786000545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Age on the Diagnostic Yield of Routine\n                    <scp>EEG<\/scp>\n                    in People With Childhood or Juvenile Absence Epilepsy: A Cross\u2010Sectional Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-7809","authenticated-orcid":false,"given":"Francesco","family":"Fortunato","sequence":"first","affiliation":[{"name":"Institute of Neurology, Department of Medical and Surgical Sciences Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9366-1582","authenticated-orcid":false,"given":"Alessia","family":"Giugno","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Department of Medical and Surgical Sciences Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Sturniolo","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Department of Medical and Surgical Sciences Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3422-972X","authenticated-orcid":false,"given":"Enrico","family":"Fratto","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Department of Medical and Surgical Sciences Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pio","family":"Zoleo","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Department of Medical and Surgical Sciences Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2444-8761","authenticated-orcid":false,"given":"Francesca Felicia","family":"Operto","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Department of Medical and Surgical Sciences Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4136-9245","authenticated-orcid":false,"given":"Ilaria","family":"Sammarra","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Department of Medical and Surgical Sciences Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7384-3074","authenticated-orcid":false,"given":"Antonio","family":"Gambardella","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Department of Medical and Surgical Sciences Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"issue":"6","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1111\/epi.18338","article-title":"Updated Classification of Epileptic Seizures: 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