{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:04:33Z","timestamp":1789646673149,"version":"4.0.0"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Distinguishing pathological changes from physiological adaptations in pregnancy\u2010related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune\u2010inflammation, and dehydration status in these patients and assess their prognostic value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, 120 participants were categorized into four groups: CVT with pregnancy\u2010puerperium, CVT without pregnancy\u2010puerperium, pregnancy\u2010puerperium without CVT, and healthy nonpregnant female controls (30 per group). Laboratory indices were compared across groups. Neurological severity and functional outcomes were assessed using the National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS) at admission, 7\u2009days, and 3\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with CVT without pregnancy\u2010puerperium, CVT with pregnancy\u2010puerperium presented earlier after symptom onset and exhibited more severe neurological manifestations. CVT with pregnancy\u2010puerperium showed higher fibrinogen and D\u2010dimer levels than CVT without pregnancy\u2010puerperium and healthy nonpregnant controls, but these markers overlapped with healthy pregnancy\u2010puerperium controls. Several inflammatory markers were elevated compared with non\u2010pregnancy groups, while neutrophil count, NLR, SII, and CRP overlapped with healthy pregnancy\u2010puerperium controls. Elevated urine specific gravity was more frequent in CVT with pregnancy\u2010puerperium than in healthy pregnancy\u2010puerperium controls. Within this group, D\u2010dimer and inflammatory markers correlated positively with NIHSS and mRS scores at admission and 7\u2009days. Plasma osmolality &gt;\u2009310\u2009mOsm\/(kg\u00b7H\n                      <jats:sub>2<\/jats:sub>\n                      O) was associated with worse neurological outcomes at 7\u2009days and 3\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>CVT during pregnancy\u2010puerperium occurs against pregnancy\u2010related hypercoagulability, immune\u2010inflammatory activation, and fluid\u2010balance changes, with overlap between pathological CVT\u2010related changes and physiological pregnancy adaptations. D\u2010dimer, inflammatory indices, and dehydration\u2010related parameters may provide prognostic information for risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70518","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:44:18Z","timestamp":1789645458000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in Immune\u2010Inflammation Status and Prognosis in Pregnancy\u2010Related Cerebral Venous Thrombosis"],"prefix":"10.1002","author":[{"given":"Xiaoming","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Advanced Center of Stroke, Beijing Institute for Brain Disorders  Beijing China"},{"name":"National Center for Neurological Disorders Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research 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Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9169-6845","authenticated-orcid":false,"given":"Chunxiao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Advanced Center of Stroke, Beijing Institute for Brain Disorders  Beijing China"},{"name":"National Center for Neurological Disorders Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Geriatric Diseases Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital 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