{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:55:58Z","timestamp":1790679358057,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Seizure detection devices can improve the safety of children with epilepsy, yet high false alarms limit their clinical applicability. Here, we investigated whether specific time periods are disproportionately prone to false alarms. We analyzed 2876 NightWatch alarms occurring between 19:00 and 09:00 in 65 children (ages 3\u201316, 48% female). Temporal distributions differed significantly between true and false alarms (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with a significant divergence in skewness (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001); notably, 30% of false alarms occurred between 06:00 and 09:00. This suggests NightWatch performance is adversely affected by wakefulness and morning arousal. Our findings support exploring time\u2010 or state\u2010dependent detection thresholds to reduce false alarms.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    The PROMISE (NCT03909984) and LICSENSE (NTR4115\/NR395) trials were registered at the Dutch Trial Registry.\n                  <\/jats:p>","DOI":"10.1002\/acn3.70530","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:03:18Z","timestamp":1790676198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6625-7923","authenticated-orcid":false,"given":"Mohammad","family":"Shahbakhti","sequence":"first","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland (SEIN)  Heemstede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5384-9975","authenticated-orcid":false,"given":"Anemoon T.","family":"Bosch","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland (SEIN)  Heemstede the Netherlands"},{"name":"Department of Neurology Leiden University Medical Centre (LUMC)  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1071-6769","authenticated-orcid":false,"given":"Job","family":"van der Palen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Medisch Spectrum Twente  Enschede the Netherlands"},{"name":"Section Cognition, Data and Education, Faculty of Behavioural, Management and Social Sciences University of Twente  Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2603-3364","authenticated-orcid":false,"given":"Franciscus S.","family":"Leijten","sequence":"additional","affiliation":[{"name":"Brain Center, Department of Neurology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6188-2973","authenticated-orcid":false,"given":"Johannes P.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Academic Center of Epileptology Kempenhaeghe  Heeze the Netherlands"},{"name":"Faculty of Electrical Engineering Eindhoven University of Technology  Eindhoven the Netherlands"},{"name":"Department of Orthodontics Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5570-8872","authenticated-orcid":false,"given":"Richard H. C.","family":"Lazeron","sequence":"additional","affiliation":[{"name":"Academic Center of Epileptology Kempenhaeghe  Heeze the Netherlands"},{"name":"Faculty of Electrical Engineering Eindhoven University of Technology  Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1435-8970","authenticated-orcid":false,"given":"Roland D.","family":"Thijs","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland (SEIN)  Heemstede the Netherlands"},{"name":"Department of Neurology Leiden University Medical Centre (LUMC)  Leiden the Netherlands"},{"name":"UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"12","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/s41582-021-00574-w","article-title":"Autonomic Manifestations of Epilepsy: Emerging Pathways to Sudden Death?","volume":"17","author":"Thijs R. D.","year":"2021","journal-title":"Nature Reviews Neurology"},{"issue":"17","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1212\/WNL.0000000000003685","article-title":"Practice Guideline Summary: Sudden Unexpected Death in Epilepsy Incidence Rates and Risk Factors","volume":"88","author":"Harden C.","year":"2017","journal-title":"Neurology"},{"issue":"1","key":"e_1_2_12_4_1","first-page":"S11","article-title":"Seizure Detection at Home: Do Devices on the Market Match the Needs of People Living With Epilepsy and Their Caregivers?","volume":"61","author":"Bruno E.","year":"2020","journal-title":"Epilepsia"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.21037\/mhealth-24-7","article-title":"Performance, Impact and Experiences of Using Wearable Devices for Seizure Detection in Community\u2010Based Settings: A Mixed Methods Systematic Review","volume":"10","author":"Sasseville M.","year":"2024","journal-title":"Mhealth"},{"issue":"3","key":"e_1_2_12_6_1","first-page":"S72","article-title":"Real\u2010World User Experience With Seizure Detection Wearable Devices in the Home Environment","volume":"64","author":"Hadady L.","year":"2023","journal-title":"Epilepsia"},{"issue":"1","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/epi.18280","article-title":"Users' Perspectives and Preferences on Using Wearables in Epilepsy: A Critical Review","volume":"66","author":"Hadady L.","year":"2025","journal-title":"Epilepsia"},{"issue":"12","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1111\/epi.18534","article-title":"How Often Do Caregivers Attend Their Child When a Seizure Detection Device Alerts for a Nocturnal Major Motor Seizure?","volume":"66","author":"Bosch A. T.","year":"2025","journal-title":"Epilepsia"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105952","article-title":"Seizure Detection Using Wearable Electrocardiogram Connected to a Smartphone: A Phase 3 Clinical Validation Study","volume":"120","author":"Jeppesen J.","year":"2025","journal-title":"eBioMedicine"},{"issue":"8","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1111\/epi.18021","article-title":"Detection of Focal to Bilateral Tonic\u2010Clonic Seizures Using a Connected Shirt","volume":"65","author":"Gharbi O.","year":"2024","journal-title":"Epilepsia"},{"issue":"2","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/epd2.20196","article-title":"Detection of Seizures With Ictal Tachycardia, Using Heart Rate Variability and Patient Adaptive Logistic Regression Machine Learning Methods: A Hospital\u2010Based Validation Study","volume":"26","author":"Jeppesen J.","year":"2024","journal-title":"Epileptic Disorders"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2025.109087","article-title":"Detection of Nocturnal Epileptic Seizures Using a Wearable Armband: A Deep Learning Approach Combining Accelerometry and Photoplethysmography Signals","volume":"273","author":"Dong C.","year":"2026","journal-title":"Computer Methods and Programs in Biomedicine"},{"issue":"8","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1111\/epi.17654","article-title":"Multimodal Nocturnal Seizure Detection in Children With Epilepsy: A Prospective, Multicenter, Long\u2010Term, In\u2010Home Trial","volume":"64","author":"Westrhenen A.","year":"2023","journal-title":"Epilepsia"},{"issue":"3","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/epi4.12618","article-title":"Multimodal Nocturnal Seizure Detection: Do we Need to Adapt Algorithms for Children?","volume":"7","author":"Lazeron R. H. C.","year":"2022","journal-title":"Epilepsia Open"},{"issue":"18","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.724904","article-title":"Prospective Study of a Multimodal Convulsive Seizure Detection Wearable System on Pediatric and Adult Patients in the Epilepsy Monitoring Unit","volume":"12","author":"Onorati F.","year":"2021","journal-title":"Frontiers in Neurology"},{"issue":"6","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S1474-4422(13)70075-9","article-title":"Prediction of Seizure Likelihood With a Long\u2010Term, Implanted Seizure Advisory System in Patients With Drug\u2010Resistant Epilepsy: A First\u2010In\u2010Man Study","volume":"12","author":"Cook M. J.","year":"2013","journal-title":"Lancet Neurology"},{"issue":"5","key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/epi.17202","article-title":"Parental Preferences for Seizure Detection Devices: A Discrete Choice Experiment","volume":"63","author":"Westrhenen A.","year":"2022","journal-title":"Epilepsia"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.70530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:03:20Z","timestamp":1790676200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.70530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":16,"alternative-id":["10.1002\/acn3.70530"],"URL":"https:\/\/doi.org\/10.1002\/acn3.70530","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"acn3.70530"}}