{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:58:08Z","timestamp":1791464288639,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 NS122038"],"award-info":[{"award-number":["K23 NS122038"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG062429"],"award-info":[{"award-number":["P30 AG062429"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1 AG082726"],"award-info":[{"award-number":["RF1 AG082726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain\u2010specific cognitive trajectories among cognitively unimpaired persons with de novo PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Cognitively unimpaired participants with SCC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009294) and without SCC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009857) from the Parkinson's Progression Markers Initiative underwent neuropsychological testing, lumbar puncture, and dopamine transporter (DaT) single\u2010photon emission computed tomography (SPECT). Multiple regression analyses examined SCC associations with biomarkers of AD (CSF phosphorylated\u2010tau181\/amyloid\u2010beta42 [p\u2010tau181\/A\u03b242]), neurodegeneration (CSF neurofilament light [NfL]), and PD (DaT\u2010SPECT in contralateral putamen). Linear mixed effects models examined 5\u2010year cognitive trajectories (working memory, category fluency, learning and memory, visuospatial functioning, processing speed) by SCC status and the extent to which biomarkers of AD, neurodegeneration, and PD moderated these associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      At baseline, the SCC group had higher p\u2010tau181\/A\u03b242 (FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) than the No SCC group, while NfL and DaT\u2010SPECT did not differ. Relative to the No SCC group, the SCC group exhibited faster decline in learning (FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), delayed recall (FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016) and working memory (FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016). AD and PD\u2010related biomarkers moderated cognitive trajectories: SCC in combination with (1) higher CSF p\u2010tau181\/A\u03b242 was related to steeper declines in working memory (FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032);\n                      <jats:italic>and<\/jats:italic>\n                      (2) lower DaT\u2010SPECT was related to steeper declines in delayed recall (FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>SCC is related to AD biomarkers and accelerated cognitive decline in the earliest stages of PD. SCC may serve as an early marker of cognitive risk, especially among persons with greater AD\u2010 or PD\u2010related burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70531","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:14:27Z","timestamp":1791461667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-7326","authenticated-orcid":false,"given":"Francesca V.","family":"Lopez","sequence":"first","affiliation":[{"name":"VA San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fareshte","family":"Erani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Bangen","sequence":"additional","affiliation":[{"name":"VA San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Coughlin","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Galasko","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey R.","family":"Thomas","sequence":"additional","affiliation":[{"name":"VA San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-021-00280-3","article-title":"Parkinson Disease\u2010Associated Cognitive Impairment","volume":"7","author":"Aarsland D.","year":"2021","journal-title":"Nature Reviews Disease Primers"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fnagi.2019.00021","article-title":"Incidence of Mild Cognitive Impairment and Dementia in Parkinson's Disease: The Parkinson's Disease Cognitive Impairment Study","volume":"11","author":"Nicoletti A.","year":"2019","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"12","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1212\/WNL.0b013e3181f39d0e","article-title":"Mild Cognitive Impairment in Parkinson Disease: A Multicenter Pooled Analysis","volume":"75","author":"Aarsland D.","year":"2010","journal-title":"Neurology"},{"issue":"4","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneurol.2017.27","article-title":"Cognitive Decline in Parkinson Disease","volume":"13","author":"Aarsland D.","year":"2017","journal-title":"Nature Reviews. 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