{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:55:02Z","timestamp":1791172502425,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1NS126227"],"award-info":[{"award-number":["RO1NS126227"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We characterize copine\u20104 (CPNE4)\u2010IgG and report clinical associations. Among 844 samples with unclassified neural IgGs identified by mouse\u2010brain indirect immunofluorescence assay over 2\u2009years, 5 samples (serum, 3; CSF, 2) from 3 patients produced a distinctive cerebrum\u2010restricted synaptic pattern. Protein microarray disclosed CPNE4 \u201ctop hit\u201d in those 3 patients; specificity was confirmed by 3 CPNE4\u2010specific assays (confocal IFA, cell\u2010based, and western blot). Median onset age was 67\u2009years (range 60\u201368); all had encephalitis: a brainstem syndrome during immune checkpoint inhibitor therapy for lung cancer (2) and anti\u2010NMDA\u2010receptor encephalitis accompanied by neuroectoderm\u2010lineage cancer (1). To date, CPNE4\u2010IgG has paraneoplastic encephalitis significance.<\/jats:p>","DOI":"10.1002\/acn3.70545","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:47:22Z","timestamp":1791172042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Copine\u20104 Paraneoplastic Autoimmune Encephalitis"],"prefix":"10.1002","author":[{"given":"Mimi S.","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Ml","family":"Quek","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Division of Neurology, Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Division of Neuroimaging, Department of Diagnostic Imaging National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Adeli","sequence":"additional","affiliation":[{"name":"Neurology The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle N.","family":"Conway","sequence":"additional","affiliation":[{"name":"Marshall University Medical Center  Huntington West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie E.","family":"Lesnick","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Anissian","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4302-4075","authenticated-orcid":false,"given":"Divyanshu","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Mills","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6140-5584","authenticated-orcid":false,"given":"Sean J.","family":"Pittock","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1960-9065","authenticated-orcid":false,"given":"Anastasia","family":"Zekeridou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gilligan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6856-8143","authenticated-orcid":false,"given":"Andrew","family":"McKeon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1474-4422(15)00401-9","article-title":"A Clinical Approach to Diagnosis of Autoimmune Encephalitis","volume":"15","author":"Graus F.","year":"2016","journal-title":"Lancet Neurology"},{"issue":"3","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1212\/CPJ.0000000000200151","article-title":"Autoimmune Encephalitis Criteria in Clinical Practice","volume":"13","author":"Orozco 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Neuroimmunology"},{"issue":"11","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1001\/jamaneurol.2020.2231","article-title":"Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch\u2010Like Protein\u201011 Encephalitis","volume":"77","author":"Dubey D.","year":"2020","journal-title":"JAMA Neurology"},{"issue":"2","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1212\/WNL.0000000000012122","article-title":"Autoimmune Encephalitis Related to Cancer Treatment With Immune Checkpoint Inhibitors: A Systematic Review","volume":"97","author":"Nersesjan V.","year":"2021","journal-title":"Neurology"},{"issue":"3","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/acn3.70238","article-title":"Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies","volume":"13","author":"Gilligan M.","year":"2025","journal-title":"Annals of 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S.","year":"2014","journal-title":"Clinical Cancer Research"},{"issue":"3","key":"e_1_2_10_15_1","doi-asserted-by":"crossref","DOI":"10.3390\/biom14030255","article-title":"Copines, a Family of Calcium Sensor Proteins and Their Role in Brain Function","volume":"14","author":"Khvotchev M.","year":"2024","journal-title":"Biomolecules"},{"issue":"1","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0014-5793(98)00497-9","article-title":"N\u2010Copine: A Novel Two C2\u2010Domain\u2010Containing Protein With Neuronal Activity\u2010Regulated Expression","volume":"428","author":"Nakayama T.","year":"1998","journal-title":"FEBS Letters"},{"key":"e_1_2_10_17_1","unstructured":"Human Protein Atlas \u201cThe Open Access Resource for Human Proteins [Database on the Internet] \u201d 2025 https:\/\/www.proteinatlas.org\/."},{"issue":"6","key":"e_1_2_10_18_1","first-page":"2369","article-title":"High Expression of Copine 1 Promotes Cell Growth and Metastasis in Human Lung Adenocarcinoma","volume":"53","author":"Liu S.","year":"2018","journal-title":"International Journal of Oncology"},{"issue":"1","key":"e_1_2_10_19_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-026-03793-4","article-title":"Copine\u20105\u2010IgG\u2010Related Autoimmune Encephalitis: A Novel Paraneoplastic Neurological Syndrome With a Strong Melanoma Association","volume":"23","author":"Elstner M.","year":"2026","journal-title":"Journal of Neuroinflammation"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.70545","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:47:26Z","timestamp":1791172046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.70545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,4]]},"references-count":18,"alternative-id":["10.1002\/acn3.70545"],"URL":"https:\/\/doi.org\/10.1002\/acn3.70545","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,4]]},"assertion":[{"value":"2026-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"acn3.70545"}}