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Multiple sclerosis (MS) is commonly associated with comorbidities for which GLP\u20101RAs are indicated. An increasing prevalence of comorbid chronic diseases has increased the number of people living with MS (pwMS) who are prescribed a GLP\u20101RA, for indications of obesity, diabetes, obstructive sleep apnea, metabolic\u2010associated steatohepatitis, and\/or chronic kidney disease. This review addresses the following key considerations: (1) the use of GLP\u20101RAs for weight loss in pwMS and obesity, including considerations related to drug tolerability and safety; (2) the efficacy of the GLP\u20101RAs for their approved non\u2010MS indications in pwMS; and (3) the potentially pleiotropic effects of the GLP\u20101RAs on the MS disease course beyond their approved indications.<\/jats:p>","DOI":"10.1002\/acn3.70547","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:36:40Z","timestamp":1791790600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glucagon\u2010Like Peptide\u20101 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1266-6697","authenticated-orcid":false,"given":"Audrey Y.","family":"Chang","sequence":"first","affiliation":[{"name":"Division of MS and Neuroimmunology, Davee Department of Neurology Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4293-8115","authenticated-orcid":false,"given":"Farrah J.","family":"Mateen","sequence":"additional","affiliation":[{"name":"Division of MS and Neuroimmunology, Davee Department of Neurology Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"A.Montero G.Sparks M.Presiado andL.Hamel \u201cKFF Health Tracking Poll May 2024: The Public's Use and Views of GLP\u20101 Drugs \u201d KFF (2024) https:\/\/www.kff.org\/health\u2010costs\/kff\u2010health\u2010tracking\u2010poll\u2010may\u20102024\u2010the\u2010publics\u2010use\u2010and\u2010views\u2010of\u2010glp\u20101\u2010drugs\/."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001931\u2010z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.140"},{"key":"e_1_2_10_5_1","unstructured":"\u201cGLP\u20101 Agonists. 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