{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:43:50Z","timestamp":1792503830493,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR206110"],"award-info":[{"award-number":["NIHR206110"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the incidence of diabetes mellitus and its associations with hospitalisation and mortality in adults with multiple sclerosis (MS) and matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using English primary care data from the Clinical Practice Research Datalink, linked to hospital and mortality records, we matched adults with MS with up to 10 controls without MS by age, sex and practice. We excluded individuals with pre\u2010existing diabetes mellitus. Outcomes included all\u2010cause hospitalisation (number and duration) and mortality. We used Poisson, negative binomial, linear and Cox proportional hazards models, adjusting for demographic and socioeconomic factors, with interaction terms for ethnicity, deprivation and urbanity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 47,247 individuals with MS and 458,951 matched controls. Over a mean follow\u2010up of 15.2\u2009years, people with MS had a higher incidence of diabetes mellitus (adjusted incidence rate ratio\u2009=\u20091.16, 95% confidence interval 1.11\u20131.21). Among people with MS, incident diabetes mellitus was associated with higher hospitalisation rates (adjusted incidence rate ratio\u2009=\u20091.52, 1.42\u20131.64), longer hospitalisation duration (median 12 vs. 2\u2009days) and increased mortality (adjusted hazard ratio\u2009=\u20091.41, 1.31\u20131.49). Similar patterns were observed among controls. The association between diabetes mellitus and increased hospitalisation was stronger in rural areas among those with MS and in White groups among controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>MS was associated with a higher incidence of diabetes mellitus, which was in turn associated with greater hospitalisation and mortality. These findings may support consideration of equitable screening, prevention and management of diabetes mellitus in people living with MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70548","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:20:26Z","timestamp":1792502426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incident Comorbid Diabetes and Outcomes in Multiple Sclerosis: An English Population\u2010Based Cohort Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2896-6127","authenticated-orcid":false,"given":"Yolanda","family":"Lau","sequence":"first","affiliation":[{"name":"Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-0862","authenticated-orcid":false,"given":"Sedigheh","family":"Zabihi","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Population Health Queen Mary University of London  London UK"},{"name":"Faculty of Population Health Sciences, Institute of Health Informatics UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-9040","authenticated-orcid":false,"given":"Morghan","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6475-9006","authenticated-orcid":false,"given":"Georgina","family":"Mathlin","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8083-7649","authenticated-orcid":false,"given":"Sube","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebaa","family":"Marouf","sequence":"additional","affiliation":[{"name":"DeNPRU\u2010QM Patient and Public Engagement Group  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Hadley","sequence":"additional","affiliation":[{"name":"DeNPRU\u2010QM Patient and Public Engagement Group  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2777-7616","authenticated-orcid":false,"given":"Claudia","family":"Cooper","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2993-585X","authenticated-orcid":false,"given":"Ruth","family":"Dobson","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1212\/WNL.0000000000000768","article-title":"Atlas of Multiple Sclerosis 2013: A Growing Global Problem With Widespread Inequity","volume":"83","author":"Browne P.","year":"2014","journal-title":"Neurology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising Prevalence of Multiple Sclerosis Worldwide: Insights From the Atlas of MS, Third Edition","volume":"26","author":"Walton C.","year":"2020","journal-title":"Multiple Sclerosis"},{"key":"e_1_2_11_4_1","unstructured":"MS Society \u201cMS in the UK \u201dhttps:\/\/www.mssociety.org.uk\/what\u2010we\u2010do\/our\u2010work\/our\u2010evidence\/ms\u2010in\u2010the\u2010uk."},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s00415-025-13112-1","article-title":"Mortality and Causes of Death for People With Multiple Sclerosis: A Finnish Nationwide Register Study","volume":"272","author":"Kuutti K.","year":"2025","journal-title":"Journal of Neurology"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2024.105943","article-title":"Comorbidities and Their Association With Outcomes in the Multiple Sclerosis Population: A Rapid Review","volume":"92","author":"Frank H. 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