{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:47:04Z","timestamp":1792583224112,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006529","name":"Bundesamt f\u00fcr Strahlenschutz","doi-asserted-by":"publisher","award":["3621SNA403"],"award-info":[{"award-number":["3621SNA403"]}],"id":[{"id":"10.13039\/501100006529","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sleep disturbances have been implicated as a risk factor for developing Alzheimer's disease (AD), but evidence linking plasma AD biomarkers to sleep in cognitively unimpaired individuals remains limited. The present study examined associations between evening, morning, and overnight changes in plasma AD biomarkers and measures of sleep macro\u2010 and microstructure and subjective sleep quality in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty cognitively unimpaired adults aged 55 to 75\u2009years (20 females) without sleep or mental disorders underwent overnight polysomnography. Plasma AD biomarkers p\u2010tau181, p\u2010tau217, t\u2010tau, A\u03b242, A\u03b240, and A\u03b242\/40 were assessed in the evening and in the morning and related to sleep macro\u2010 and microstructure (sleep spindles, EEG spectral power), and subjective sleep measures by using correlational analyzes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher evening t\u2010tau and p\u2010tau181 were associated with reduced N3 sleep, whereas higher morning t\u2010tau and greater overnight increases in t\u2010tau were related to longer nocturnal wakefulness. Amyloid\u2010\u03b2 measures showed the most consistent associations with sleep microstructure. Higher A\u03b242 and A\u03b240 concentrations were associated with shorter duration and lower density of sleep spindles, particularly at frontal sites. Higher evening and morning amyloid\u2010\u03b2 concentrations were also associated with lower alpha, beta, and spindle\u2010frequency EEG power, mainly during non\u2010rapid eye movement sleep. Tau associations with EEG spectral power were less consistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>In cognitively unimpaired older adults, plasma AD biomarkers were associated with PSG sleep features, especially amyloid\u2010\u03b2 markers with sleep microstructure. These exploratory, correlational findings suggest that sleep spindles and spectral power may reflect early AD\u2010related biological processes but require replication in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70562","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:32:41Z","timestamp":1792582361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Biomarkers of Alzheimer's Disease and Sleep in Cognitively Unimpaired Older Adults"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-2773","authenticated-orcid":false,"given":"Cornelia","family":"Sauter","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Competence Center of Sleep Medicine Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t at Berlin and Humboldt Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Dorn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Competence Center of Sleep Medicine Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t at Berlin and Humboldt Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Hellmann\u2010Regen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Clinical Neurobiology Lab Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t at Berlin and Humboldt Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Bueno\u2010Lopez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Competence Center of Sleep Medicine Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t at Berlin and Humboldt Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Sant Pau Memory Unit Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"van Ginneken","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Competence Center of Sleep Medicine Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t at Berlin and Humboldt Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Danker\u2010Hopfe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Competence Center of Sleep Medicine Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of the Freie Universit\u00e4t at Berlin and Humboldt Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization \u201cDementia \u2010 Fact Sheet \u201d2025 https:\/\/www.who.int\/en\/news\u2010room\/fact\u2010sheets\/detail\/dementia."},{"key":"e_1_2_11_3_1","first-page":"77","volume-title":"Multi\u2010Factorial Approach as a Therapeutic Strategy for the Management of Alzheimer's Disease","author":"Boiko D. 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