{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:09:14Z","timestamp":1790460554086,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/N014391\/1"],"award-info":[{"award-number":["EP\/N014391\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K013998\/1"],"award-info":[{"award-number":["MR\/K013998\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N026063\/1"],"award-info":[{"award-number":["MR\/N026063\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Slowing and frontal spread of the alpha rhythm have been reported in multiple epilepsy syndromes. We investigated whether these phenomena are associated with seizure control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively acquired resting\u2010state electroencephalogram (<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>) in 63 patients with focal and idiopathic generalized epilepsy (<jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content>) and 39 age\u2010 and gender\u2010matched healthy subjects (HS). Patients were divided into good and poor (\u22654 seizures\/12\u00a0months) seizure control groups based on self\u2010reports and clinical records. We computed spectral power from 20\u2010sec <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> segments during eyes\u2010closed wakefulness, free of interictal abnormalities, and quantified power in high\u2010 and low\u2010alpha bands. Analysis of covariance and post hoc <jats:italic>t<\/jats:italic>\u2010tests were used to assess group differences in alpha\u2010power shift across all <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> channels. Permutation\u2010based statistics were used to assess the topography of this shift across the whole scalp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to HS, patients showed a statistically significant shift of spectral power from high\u2010 to low\u2010alpha frequencies (effect size <jats:italic>g<\/jats:italic>\u00a0=\u00a00.78 [95% confidence interval 0.43, 1.20]). This alpha\u2010power shift was driven by patients with poor seizure control in both <jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content> (<jats:italic>g<\/jats:italic>\u00a0=\u00a01.14, [0.65, 1.74]), and occurred over midline frontal and bilateral occipital regions. <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content> exhibited less alpha power shift compared to <jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content> over bilateral frontal regions (<jats:italic>g<\/jats:italic>\u00a0=\u00a0\u22121.16 [\u22120.68, \u22121.74]). There was no interaction between syndrome and seizure control. Effects were independent of antiepileptic drug load, time of day, or subgroup definitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Alpha slowing and anteriorization are a robust finding in patients with epilepsy and might represent a generic indicator of seizure liability.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.710","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T05:14:24Z","timestamp":1545196464000},"page":"333-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Slower alpha rhythm associates with poorer seizure control in epilepsy"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9356-1450","authenticated-orcid":false,"given":"Eugenio","family":"Abela","sequence":"first","affiliation":[{"name":"Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology and Neuroscience King's College London London United Kingdom"},{"name":"Department of Clinical Neurophysiology King's College Hospital NHS Foundation Trust London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam D.","family":"Pawley","sequence":"additional","affiliation":[{"name":"Social, Genetic and Developmental Psychiatry Research Center Institute of Psychiatry, Psychology and Neuroscience King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chayanin","family":"Tangwiriyasakul","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology and Neuroscience King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5084-1973","authenticated-orcid":false,"given":"Siti N.","family":"Yaakub","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology and Neuroscience King's College London London United Kingdom"},{"name":"School of Biomedical Engineering &amp; Imaging Sciences King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahmida A.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery UCL Hospitals NHS Foundation Trust London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D. C.","family":"Elwes","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology King's College Hospital NHS Foundation Trust London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Brunnhuber","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology King's College Hospital NHS Foundation Trust London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology and Neuroscience King's College London London United Kingdom"},{"name":"Department of Clinical Neurophysiology King's College Hospital NHS Foundation Trust London United 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