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We described a new family, in which affected individuals exhibited pure hereditary spastic paraplegia with benign clinical course. Exome sequencing revealed a novel nonsense variant in the <jats:italic><jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content>1C<\/jats:italic> gene. The level of <jats:italic><jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content>1C<\/jats:italic> mutant transcript significantly decreased compared to that of wild\u2010type transcript, and can be recovered after cycloheximide administration, which indicated that nonsense\u2010mediated <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> decay was a mechanism that might be responsible for the phenotype. Our findings expanded the clinical and genetic spectrum of <jats:styled-content style=\"fixed-case\">SPG<\/jats:styled-content>73.<\/jats:p>","DOI":"10.1002\/acn3.717","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T19:26:22Z","timestamp":1546629982000},"page":"610-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A novel <i><scp>CPT<\/scp>1C<\/i> variant causes pure hereditary spastic paraplegia with benign clinical course"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9814-2514","authenticated-orcid":false,"given":"Daojun","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Neurology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking University People's 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