{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:31:02Z","timestamp":1770741062233,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T00:00:00Z","timestamp":1551571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>TLR4 plays an important role in the pathogenesis of Guillain\u2010Barr\u00e9 syndrome (GBS). The relationships between <jats:italic>TLR4<\/jats:italic> polymorphisms and susceptibility to GBS are poorly understood. We investigated the frequency and assessed the association of two single nucleotide polymorphisms (SNPs) in the extracellular domain of <jats:italic>TLR4<\/jats:italic> (Asp299Gly and Thr399Ile) with disease susceptibility and the clinical features of GBS in a Bangladeshi cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 290 subjects were included in this study: 141 patients with GBS and 149 unrelated healthy controls. The <jats:italic>TLR4<\/jats:italic> polymorphisms Asp299Gly and Thr399Ile were genotyped using polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP) assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The minor 299Gly allele was significantly associated with GBS susceptibility (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0137, OR\u00a0=\u00a01.97, 95% CI\u00a0=\u00a01.17\u20133.31), and was present at a significantly higher frequency in patients with the acute motor axonal neuropathy (AMAN) subtype of GBS (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0120, OR\u00a0=\u00a02.37, 95% CI\u00a0=\u00a01.26\u20134.47) than acute inflammatory demyelinating polyneuropathy (AIDP) subtype (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.961, OR\u00a0=\u00a01.15, 95% CI\u00a0=\u00a00.38\u20133.48); when compared to healthy controls. The genotype frequency of the Asp299Gly polymorphism was not significantly different between patients with GBS and healthy controls. The Asp299\u2010Thr399 haplotype was associated with a significantly lower risk of developing GBS (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0451, OR\u00a0=\u00a00.63, 95% CI\u00a0=\u00a00.40\u20130.99). No association was observed between the Thr399Ile polymorphism and GBS disease susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The <jats:italic>TLR4<\/jats:italic> minor 299Gly allele was associated with increased susceptibility to GBS and the axonal GBS subtype in the Bangladeshi population. However, no associations were observed between the genotypes of the Asp299Gly and Thr399Ile SNPs and antecedent <jats:italic>C. jejuni<\/jats:italic> infection or disease severity in Bangladeshi patients with GBS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.744","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T02:36:45Z","timestamp":1551667005000},"page":"708-715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Toll\u2010like receptor\u20104 299Gly allele is associated with Guillain\u2010Barr\u00e9 syndrome in Bangladesh"],"prefix":"10.1002","volume":"6","author":[{"given":"Israt","family":"Jahan","sequence":"first","affiliation":[{"name":"Laboratory Sciences and Services Division icddr,b Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rijwan U.","family":"Ahammad","sequence":"additional","affiliation":[{"name":"Laboratory Sciences and Services 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Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badrul","family":"Islam","sequence":"additional","affiliation":[{"name":"Laboratory Sciences and Services Division icddr,b Dhaka Bangladesh"},{"name":"Department of Medical Microbiology and Infectious Diseases Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quazi D.","family":"Mohammad","sequence":"additional","affiliation":[{"name":"National Institute of Neurosciences and Hospital Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0935-8079","authenticated-orcid":false,"given":"Zhahirul","family":"Islam","sequence":"additional","affiliation":[{"name":"Laboratory Sciences and Services Division icddr,b Dhaka 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