{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:58:57Z","timestamp":1777417137559,"version":"3.51.4"},"reference-count":80,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Essential tremor (ET) is one of the most common adult movement disorders, characterized by clinical tremor and other nonmotor symptoms. It is a progressive disease that shares features with other neurodegenerative diseases. ET is a complex disease with both genetic and environmental underpinnings. While genetic forms of ET are well recognized, the role of environmental and lifestyle factors in ET has been debated. Studies suggest that exposure to neurotoxic compounds such as <jats:italic>\u03b2<\/jats:italic>\u2010carboline alkaloids and ethanol are potential risk factors for ET, while antioxidant intake may be protective. In addition, smoking acts as a protective factor in ET, parallel to its effects in other neurological diseases. New evidence points to pesticide and lead exposure as potential risk factors. There is growing evidence to suggest that environmental and lifestyle factors play a role in ET but additional research is needed in order to completely understand their cause and effect association. There is also a need for larger case\u2010control and prospective cohort studies across different populations to further evaluate the etiological importance of these factors in ET.<\/jats:p>","DOI":"10.1002\/acn3.758","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T05:16:02Z","timestamp":1556774162000},"page":"979-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Etiologic links between environmental and lifestyle factors and Essential tremor"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0849-6226","authenticated-orcid":false,"given":"Yi\u2010Lin","family":"Ong","sequence":"first","affiliation":[{"name":"Duke\u2010NUS Medical School Singapore Singapore"},{"name":"National Neuroscience Institute Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Deng","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eng\u2010King","family":"Tan","sequence":"additional","affiliation":[{"name":"Duke\u2010NUS Medical School Singapore Singapore"},{"name":"National Neuroscience Institute Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22838"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22755"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.11.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.4.400"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03122.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318297ef2b"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2005.04.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21376"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000086376.40750.AF"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000033798.85208.F2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21553"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b389f1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01923.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.037176"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.05.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-011-0291-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-013-0545-0"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.5334\/tohm.248","article-title":"Motor and non\u2010motor features: differences between patients with isolated essential tremor and patients with both essential tremor and Parkinson's disease","volume":"5","author":"Ghika A","year":"2015","journal-title":"Tremor Other Hyperkinet Mov (NY)"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm266"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.147223"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.05.003"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-84"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120605"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl120"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.299"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31825fdeed"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.07.002"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1419581111"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv281"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20950"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25949-w"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.8.1389"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000103236.26934.41"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00606-9"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2010.159"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000038385.60538.19"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.12.001"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2012.09.004"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2008.02.013"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2013.07.002"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000266663.27398.9f"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2003.10.044"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(93)90049-5"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.1.39"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172352.88359.2d"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122333"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2525967"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520360068014"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704243361704"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070778"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000084713"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111579"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000994"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390515"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523625"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000103646"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20035"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.09.042"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.05.015"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.01.058"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2006.00748.x"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.162701"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23603"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1693"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652030210145892"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.09.007"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25590"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21810"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000311271.42596.32"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25028"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.2741\/2695"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.332"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2006.03.005"},{"key":"e_1_2_10_75_1","first-page":"69","article-title":"Related factors and prevalence for the essential tremor disease of Uygur residents in Hetian, Xinjiang UygurAutonomous Region","volume":"95","author":"Yao Y","year":"2015","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_10_76_1","first-page":"e00194915","article-title":"Essential tremor in endemic disease control agents exposed to pesticides: a case\u2010control study","volume":"33","author":"Azevedo MFA","year":"2017","journal-title":"Cad Saude Publ"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6404"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10352"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000145600.91491.F2"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356351"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21699"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facn3.758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.758","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T15:59:22Z","timestamp":1694361562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":80,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/acn3.758"],"URL":"https:\/\/doi.org\/10.1002\/acn3.758","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"2019-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}