{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:42:36Z","timestamp":1785300156510,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006928","name":"Ohio State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The selection of optimal deep brain stimulation (<jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>) parameters is time\u2010consuming, experience\u2010dependent, and best suited when acute effects of stimulation can be observed (e.g., tremor reduction).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To test the hypothesis that optimal stimulation location can be estimated based on the cortical connections of <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content> contacts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed a cohort of 38 patients with Parkinson's disease (24 training, and 14 test cohort). Using whole\u2010brain probabilistic tractography, we first mapped the cortical regions associated with stimulation\u2010induced efficacy (rigidity, bradykinesia, and tremor improvement) and side effects (paresthesia, motor contractions, and visual disturbances). We then trained a support vector machine classifier to categorize <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content> contacts into efficacious, defined by a therapeutic window \u22652\u00a0V (threshold for side effect minus threshold for efficacy), based on their connections with cortical regions associated with efficacy versus side effects. The connectivity\u2010based classifications were then compared with actual stimulation contacts using receiver\u2010operating characteristics (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Unique cortical clusters were associated with stimulation\u2010induced efficacy and side effects. In the training\u00a0dataset, 42 of the 47 stimulation contacts were accurately classified as efficacious, with a therapeutic window of \u22653\u00a0V in 31 (66%) and between 2 and 2.9\u00a0V in 11 (24%) electrodes. This connectivity\u2010based estimation was successfully replicated in the test cohort with similar accuracy (area under <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>\u00a0=\u00a00.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cortical connections can predict the efficacy of <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content> contacts and potentially facilitate <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content> programming. The clinical utility of this paradigm in optimizing DBS outcomes should be prospectively tested, especially for directional electrodes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.784","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T08:19:54Z","timestamp":1561537194000},"page":"1142-1150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Connectivity\u2010based selection of optimal deep brain stimulation contacts: A feasibility study"],"prefix":"10.1002","volume":"6","author":[{"given":"Vibhor","family":"Krishna","sequence":"first","affiliation":[{"name":"Center for Neuromodulation The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sammartino","sequence":"additional","affiliation":[{"name":"Center for Neuromodulation The Ohio State University Columbus 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