{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:00:54Z","timestamp":1792098054734,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T00:00:00Z","timestamp":1264723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the safety and efficacy of abatacept in patients with severe juvenile idiopathic arthritis (JIA)\u2013related uveitis refractory or intolerant to immunosuppressive and anti\u2013tumor necrosis factor \u03b1 (anti\u2010TNF\u03b1) agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with JIA\u2010related uveitis refractory to immunosuppressive and anti\u2010TNF\u03b1 agents were treated with intravenous abatacept (10 mg\/kg monthly). Side effects, frequency of uveitis flares, and ocular complications before and after treatment were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven patients (6 females and 1 male) with a mean uveitis duration of 11.6 years entered the study. All patients had failed previous immunosuppressive therapy and \u22652 anti\u2010TNF\u03b1 treatments. All patients responded to abatacept and 6 maintained a clinical remission after a mean of 9.2 months of treatment. One patient withdrew from the study with oral mycosis and arthritis flare; no other patients had side effects. The mean frequency of uveitis flares during the 6 months before and after treatment decreased from 3.7 to 0.7 episodes. No new ocular complications or worsening of preexisting ones were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Abatacept treatment led to sustained improvement in severe anti\u2010TNF\u03b1\u2013resistant JIA\u2010related uveitis and was well tolerated in all but 1 patient. These results provide new insights into a possible indication of abatacept for the treatment of uveitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.20115","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T14:06:00Z","timestamp":1264773960000},"page":"821-825","source":"Crossref","is-referenced-by-count":163,"title":["Abatacept for severe anti\u2013tumor necrosis factor \u03b1 refractory juvenile idiopathic arthritis\u2013related uveitis"],"prefix":"10.1002","volume":"62","author":[{"given":"Francesco","family":"Zulian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Balzarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Falcini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Alessio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Cimaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cimino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elisabetta","family":"Zannin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22381"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/112067210701700509"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.174"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.094698"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.065441"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.103721"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050524"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60998-8"},{"key":"e_1_2_7_10_2","first-page":"1897","article-title":"Abatacept for refractory juvenile idiopathic arthritis\u2010associated uveitis: a case report","volume":"35","author":"Angeles\u2010Han S","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22918"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.7.925"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273940600659393"},{"key":"e_1_2_7_15_2","first-page":"645","article-title":"Sarcoid\u2010related uveitis occurring during etanercept therapy","volume":"21","author":"Hashkes PJ","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0225"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.08.044"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.058248"},{"key":"e_1_2_7_19_2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1681\/ASN.V132559","article-title":"The role of novel T cell costimulatory pathways in autoimmunity and transplantation","volume":"13","author":"Yamada A","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.9.5041"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.20115","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.20115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:39:41Z","timestamp":1759423181000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.20115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,28]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1002\/acr.20115"],"URL":"https:\/\/doi.org\/10.1002\/acr.20115","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,28]]}}}