{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:50:55Z","timestamp":1789195855488,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T00:00:00Z","timestamp":1266883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the rate of joint space width (JSW) loss in both knees of patients with unilateral medial joint space narrowing (JSN) at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases were selected from a pool of 2,678 subjects enrolled in the Osteoarthritis Initiative cohort. Inclusion criteria for the present study were unilateral medial JSN, bilateral frequent knee pain, and body mass index (BMI) \u226525 kg\/m<jats:sup>2<\/jats:sup>. Baseline and 1\u2010year fixed flexion radiographs of both knees were read (blinded to time point) using an automated algorithm for minimum JSW and JSW at 4 fixed locations in the medial compartment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010seven participants met the inclusion criteria: 43 women and 24 men, with mean \u00b1 SD age 60 \u00b1 9 years and mean \u00b1 SD BMI 31 \u00b1 4 kg\/m<jats:sup>2<\/jats:sup>. Thirty\u2010seven subjects (55%) had \u22651 definite tibiofemoral osteophyte. The average progression in no\u2010JSN knees was comparable with that in JSN knees (approximately \u22120.2 mm\/year). However, JSW change was more variable in no\u2010JSN knees, resulting in standardized response means (SRMs; the mean\/SD) of approximately \u22120.24 in no\u2010JSN knees versus approximately \u22120.41 in JSN knees on average at the 4 fixed locations, and SRMs of \u22120.24 and \u22120.35, respectively, for minimum JSW. Young age and high BMI were associated with increased progression, especially in JSN knees.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>JSN and no\u2010JSN knees progressed at a comparable rate, but a wider distribution of JSW change in no\u2010JSN knees resulted in a poorer sensitivity to change in these knees.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.20149","type":"journal-article","created":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T14:16:19Z","timestamp":1266934579000},"page":"924-931","source":"Crossref","is-referenced-by-count":37,"title":["One\u2010year change in radiographic joint space width in patients with unilateral joint space narrowing: Data from the osteoarthritis initiative"],"prefix":"10.1002","volume":"62","author":[{"given":"O. D.","family":"Benichou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Guermazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Eckstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kwoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Duryea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,29]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.09.004"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.039115"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.077834"},{"key":"e_1_2_8_5_2","first-page":"139","article-title":"The long term outcome of osteoarthritis: rates and predictors of joint space narrowing in symptomatic patients with knee osteoarthritis","volume":"29","author":"Wolfe F","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115334"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.9.565"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24791"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-004-2312-6"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.082107"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.089904"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.07.008"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1118\/1.598897"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.11.001"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21122"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(07)61863-9"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.02.024"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.02.023"},{"key":"e_1_2_8_19_2","first-page":"1308","article-title":"Which is the best radiographic protocol for a clinical trial of a structure modifying drug in patients with knee osteoarthritis?","volume":"29","author":"Brandt KD","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.04.010"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.20149","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.20149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:27:58Z","timestamp":1759422478000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.20149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,29]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1002\/acr.20149"],"URL":"https:\/\/doi.org\/10.1002\/acr.20149","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,29]]}}}