{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:11:28Z","timestamp":1759425088293,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T00:00:00Z","timestamp":1266883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine whether peak work rate (W<jats:sub>peak<\/jats:sub>) can predict peak oxygen uptake (V<jats:sc>O<\/jats:sc><jats:sub>2peak<\/jats:sub>) in children with juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010one patients with JIA with a mean \u00b1 SD age of 11.4 \u00b1 2.9 years underwent a cardiopulmonary exercise test in which V<jats:sc>O<\/jats:sc><jats:sub>2peak<\/jats:sub> and W<jats:sub>peak<\/jats:sub> were determined. A multivariate regression model was used to formulate a regression equation to predict V<jats:sc>O<\/jats:sc><jats:sub>2peak<\/jats:sub> using W<jats:sub>peak<\/jats:sub> and anthropometric and demographic details. This regression equation was subsequently cross\u2010validated using an unrelated data set from children with JIA (n = 17).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The following linear regression equation to predict V<jats:sc>O<\/jats:sc><jats:sub>2peak<\/jats:sub> was established: V<jats:sc>O<\/jats:sc><jats:sub>2peak<\/jats:sub> (liters\/minute) = 0.308 + 0.146 \u00d7 sex (0 = female, 1 = male) + 0.005 \u00d7 weight (kg) + 0.008 \u00d7 W<jats:sub>peak<\/jats:sub> (W) (R<jats:sup>2<\/jats:sup> = 0.91, standard error of the estimate = 0.18 liter\/minute). Using this equation, the predicted V<jats:sc>O<\/jats:sc><jats:sub>2peak<\/jats:sub> was strongly related to the measured V<jats:sc>O<\/jats:sc><jats:sub>2peak<\/jats:sub> (r = 0.96, <jats:italic>P<\/jats:italic> &lt; 0.0001). Bland and Altman analysis revealed a mean difference of 0.01 liter\/minute and limits of agreement between \u22120.35 and 0.35 liter\/minute.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that W<jats:sub>peak<\/jats:sub> is a strong predictor of V<jats:sc>O<\/jats:sc><jats:sub>2peak<\/jats:sub> in children with JIA and may be used as a surrogate measure of V<jats:sc>O<\/jats:sc><jats:sub>2peak<\/jats:sub> in situations where it is not possible to formally assess V<jats:sc>O<\/jats:sc><jats:sub>2peak<\/jats:sub>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.20153","type":"journal-article","created":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T14:16:29Z","timestamp":1266934589000},"page":"960-964","source":"Crossref","is-referenced-by-count":4,"title":["Can peak work rate predict peak oxygen uptake in children with juvenile idiopathic arthritis?"],"prefix":"10.1002","volume":"62","author":[{"given":"Ingrid C.","family":"De Backer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davinder","family":"Singh\u2010Grewal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J. 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