{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:19:00Z","timestamp":1786976340953,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T00:00:00Z","timestamp":1268697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the safety and immunogenicity of varicella vaccine (VV) in susceptible patients with juvenile rheumatic diseases receiving methotrexate and corticosteroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010five patients with juvenile rheumatic diseases (ages 2\u201319 years) and 18 healthy children and adolescents (ages 3\u201318 years) received a single dose of VV. All 25 patients were receiving methotrexate; 13 were also receiving prednisone and 5 were also receiving other disease\u2010modifying antirheumatic drugs. None of the vaccinated patients or controls had a previous history of varicella. Anti\u2013varicella\u2010zoster virus IgG antibody (anti\u2013VZV\u2010IgG) titers were measured by enzyme\u2010linked immunosorbent assay immediately before, 4\u20136 weeks after, and 1 year after vaccination. The patients were monitored prospectively for adverse reactions related to the vaccine, exposure, and occurrence of varicella. Disease activity was assessed 3 months before and 3 months after VV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty patients and all of the controls had negative preimmunization titers of VZV\u2010IgG, and 5 patients had equivocal levels. Positive VZV\u2010IgG titers were detected in 10 (50%) of 20 seronegative patients and 13 (72.2%) of 18 controls 4\u20136 weeks after VV (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.2). One year after vaccination, 8 of 10 patients maintained positive VZV\u2010IgG titers. No overt varicella episodes and no severe adverse reactions were observed during the followup period. No worsening of clinical parameters and no flares of juvenile rheumatic diseases or changes in doses of medications used were detected after vaccination. In fact, the number of active joints in patients with juvenile idiopathic arthritis was significantly lower after VV (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>VV appears to be safe in patients with juvenile rheumatic diseases receiving methotrexate, as long as continuous prospective vigilance for side effects is performed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.20183","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T15:15:00Z","timestamp":1268752500000},"page":"1034-1039","source":"Crossref","is-referenced-by-count":86,"title":["Safety and immunogenicity of varicella vaccine in patients with juvenile rheumatic diseases receiving methotrexate and corticosteroids"],"prefix":"10.1002","volume":"62","author":[{"given":"Gecilmara Salviato","family":"Pileggi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleonice Barbosa Sandoval","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virg\u00ednia Paes Leme","family":"Ferriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69561-5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/587063"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.8.937"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.12.070"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02997.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.Supplement_3.S320"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23721"},{"key":"e_1_2_6_9_2","first-page":"1","article-title":"Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"57","author":"Harpaz R","year":"2008","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_6_10_2","first-page":"789","article-title":"Preliminary validation of clinical remission criteria using the OMERACT filter for select categories of juvenile idiopathic arthritis","volume":"33","author":"Wallace CA","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400703"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24516"},{"key":"e_1_2_6_13_2","first-page":"1058","article-title":"Preliminary definition of disease flare in juvenile rheumatoid arthritis","volume":"29","author":"Brunner HI","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.01.017"},{"key":"e_1_2_6_15_2","first-page":"1","article-title":"Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"56","author":"Marin M","year":"2007","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.196"},{"key":"e_1_2_6_17_2","first-page":"S1","article-title":"Induction and protection of autoimmune rheumatic diseases: the role of infections","volume":"26","author":"Cooke A","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.063586"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken436"},{"key":"e_1_2_6_20_2","first-page":"589","article-title":"Influenza vaccination in children with chronic rheumatic diseases and long\u2010term immunosuppressive therapy","volume":"19","author":"Kanakoudi\u2010Tsakalidou F","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_21_2","first-page":"1769","article-title":"Influenza immunization in children with chronic arthritis: a prospective study","volume":"20","author":"Malleson PN","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.013201"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22399"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00016-5"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/529043"}],"container-title":["Arthritis Care &amp; 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