{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:00Z","timestamp":1791300480985,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T00:00:00Z","timestamp":1269907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare muscle strength, physical health, and HLA\u2013DRB1 allele carriage frequencies in patients with longstanding juvenile dermatomyositis (DM) with that of controls, and to determine the presence of and risk factors for muscle weakness and magnetic resonance imaging (MRI)\u2013detected muscle damage in juvenile DM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010nine patients with juvenile DM examined a median of 16.8 years (range 2.0\u201338.1 years) after disease onset were compared with 59 age\u2010 and sex\u2010matched controls. Muscle strength\/endurance was measured by manual muscle testing (MMT) and the Childhood Myositis Assessment Scale (CMAS); health status was measured by the Short Form 36. HLA\u2013DRB1 alleles were determined by sequencing in patients and 898 healthy controls. In patients, disease activity\/damage was measured by the Disease Activity Score (DAS), Myositis Damage Index (MDI), Health Assessment Questionnaire\/Childhood Health Assessment Questionnaire, and MRI scans of the thigh muscles. Early disease characteristics were obtained by chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients had lower muscle strength\/endurance (<jats:italic>P<\/jats:italic> &lt; 0.001 for both) and physical health (<jats:italic>P<\/jats:italic> = 0.014) and increased HLA\u2013DRB1*0301 (<jats:italic>P<\/jats:italic> = 0.01) and DRB1*1401 (<jats:italic>P<\/jats:italic> = 0.003) compared with controls. In patients, persistent muscle weakness was found in 42% with MMT (score &lt;78) and in 31% with the CMAS (score &lt;48), whereas MRI\u2010detected muscle damage was found in 52%. Muscle weakness and MRI\u2010detected muscle damage were predicted by MDI muscle damage and a high DAS 1 year postdiagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A median of 16.8 years after disease onset, juvenile DM patients were weaker than the controls; muscle weakness\/reduced endurance was found in 31\u201342% of patients and MRI\u2010detected muscular damage was found in 52% of patients. The outcomes were predicted by high disease activity and muscle damage present 1 year postdiagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.20203","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T12:06:44Z","timestamp":1269950804000},"page":"1103-1111","source":"Crossref","is-referenced-by-count":71,"title":["Long\u2010term muscular outcome and predisposing and prognostic factors in juvenile dermatomyositis: A case\u2013control study"],"prefix":"10.1002","volume":"62","author":[{"given":"Helga","family":"Sanner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kirkhus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Else","family":"Merckoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Tollisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"R\u00f8island","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicte A.","family":"Lie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Taraldsrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Tore","family":"Gran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Flat\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199801000-00003"},{"key":"e_1_2_7_3_2","first-page":"31","article-title":"Juvenile dermatomyositis: medical, social and economic status in adulthood","volume":"126","author":"Chalmers A","year":"1982","journal-title":"Can Med Assoc J"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200003)43:3<541::AID-ANR9>3.0.CO;2-T"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23248"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.11.1262"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20015"},{"key":"e_1_2_7_8_2","first-page":"1693","article-title":"Magnetic resonance imaging in the idiopathic inflammatory myopathies","volume":"18","author":"Fraser DD","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.161.2.8333378"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.15.3.7624563"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200008)43:8<1866::AID-ANR24>3.0.CO;2-6"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel099"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283118711"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04498.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.209.1.9769831"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802000000200002"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24904"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem265"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371019"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.03.005"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090461"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep302"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00098-5"},{"key":"e_1_2_7_25_2","volume-title":"Physical and mental summary scales: a manual for users of version 1","author":"Ware JE","year":"2001"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10924"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg427"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230202"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371209"},{"key":"e_1_2_7_30_2","first-page":"326","article-title":"Measuring disability in juvenile dermatomyositis: validity of the Childhood Health Assessment Questionnaire","volume":"22","author":"Feldman BM","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_7_31_2","first-page":"S195","article-title":"Preliminary validation of abbreviated manual muscle testing (MMT) in the assessment of juvenile dermatomyositis (JDM)","volume":"43","author":"Hicks J","year":"2000","journal-title":"Arthritis Rheum"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199910)42:10<2213::AID-ANR25>3.0.CO;2-8"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20179"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1058-2746(03)00211-8"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2008.12.014"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken038"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.10.032"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930600622819"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20397"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283319d53"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.177.2.2217788"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.146.3.565"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9933"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22865"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22216"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23960"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.20203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.20203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:28:25Z","timestamp":1759422505000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.20203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1002\/acr.20203"],"URL":"https:\/\/doi.org\/10.1002\/acr.20203","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}