{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:08:44Z","timestamp":1790874524149,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T00:00:00Z","timestamp":1270771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Riedel's thyroiditis is a chronic fibrosing disorder of unknown etiology often associated with \u201cmultifocal fibrosclerosis.\u201d IgG4\u2010related systemic disease is characterized by IgG4+ plasma cell infiltration and fibrosis throughout many organs. We hypothesized that Riedel's thyroiditis is part of the IgG4\u2010related systemic disease spectrum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched our institution's pathology database using the terms \u201cRiedel's,\u201d \u201cstruma,\u201d \u201cthyroid,\u201d and \u201cfibrosis,\u201d and identified 3 cases of Riedel's thyroiditis. Riedel's thyroiditis was diagnosed if there was a fibroinflammatory process involving all or a portion of the thyroid gland, with evidence of extension of the process into surrounding tissues. Immunohistochemical stains for IgG4 and IgG were performed. The histopathologic and immunohistochemical features of each involved organ were evaluated. The clinical features of one patient with multiple organ system disease were described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 3 thyroidectomy samples stained positively for IgG4\u2010bearing plasma cells. One patient had extensive extrathyroidal involvement diagnostic of IgG4\u2010related systemic disease, including cholangitis, pseudotumors of both the lung and lacrimal gland, and a lymph node contiguous to the thyroid that stained intensely for IgG4+ plasma cells. The histologic features of all organs involved were consistent with IgG4\u2010related systemic disease. Patient 3 had 10 IgG4+ plasma cells per high\u2010power field initially, but rebiopsy 2 years later demonstrated no IgG4+ plasma cells. That patient's second biopsy, characterized by fibrosis and minimal residual inflammation, further solidifies the link between IgG4\u2010bearing plasma cells in tissue and the histologic evolution to Riedel's thyroiditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Riedel's thyroiditis is part of the IgG4\u2010related systemic disease spectrum. In many cases, multifocal fibrosclerosis and IgG4\u2010related systemic disease are probably the same entity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.20215","type":"journal-article","created":{"date-parts":[[2010,4,12]],"date-time":"2010-04-12T13:46:56Z","timestamp":1271080016000},"page":"1312-1318","source":"Crossref","is-referenced-by-count":273,"title":["Riedel's Thyroiditis and Multifocal Fibrosclerosis are part of the IgG4\u2010related systemic disease spectrum"],"prefix":"10.1002","volume":"62","author":[{"given":"Mollie","family":"Dahlgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arezou","family":"Khosroshahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Petur","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9,2]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"101","article-title":"Die chronische, sur bildung elsenharter tumoren f\u00fchrende entz\u00fcndung der schilddr\u00fcse","volume":"25","author":"Riedel BM","year":"1896","journal-title":"Verh Dtsch Ges Chir"},{"key":"e_1_2_6_3_2","first-page":"127","article-title":"Vorstellung eines kranken mit chronischer strumitis","volume":"26","author":"Riedel BM","year":"1897","journal-title":"Verh Dtsch Ges Chir"},{"key":"e_1_2_6_4_2","first-page":"1946","article-title":"\u00dcber verlauf und ausgang der strumitis chronica","volume":"57","author":"Riedel BM","year":"1910","journal-title":"MMW"},{"key":"e_1_2_6_5_2","first-page":"2","article-title":"Riedel's thyroiditis","volume":"12","author":"Stuart AE","year":"1959","journal-title":"Br Med J"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-17-2-201"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00507134"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1983.tb02286.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/90.6.715"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1935.01180180134006"},{"key":"e_1_2_6_11_2","first-page":"S50","article-title":"Current concepts of Riedel's thyroiditis","volume":"121","author":"Papi G","year":"2004","journal-title":"Am G Clin Pathol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)64789-2"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02967224"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(96)80045-6"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/003693300104600211"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-66-5-884"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196307042690102"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004619703"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/10507250152741046"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-200206000-00005"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1175-y"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1862-6"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-4-23"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc0902221"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05676.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60615-2"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903068"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.5414\/CNP72414"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082008001000011"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08359-9"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000136449.37936.6c"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.089169"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2046-8"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181c811ad"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02419.x"},{"key":"e_1_2_6_36_2","first-page":"908","volume-title":"Neoplastic diseases","author":"Ewing J","year":"1922"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441005"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27435"}],"container-title":["Arthritis Care &amp; 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