{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:55:17Z","timestamp":1793224517886,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess health\u2010related quality of life (HRQOL) in abatacept\u2010treated children\/adolescents with juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this phase III, double\u2010blind, placebo\u2010controlled trial, subjects with active polyarticular course JIA and an inadequate response\/intolerance to \u22651 disease\u2010modifying antirheumatic drug (including biologics) received abatacept 10 mg\/kg plus methotrexate (MTX) during the 4\u2010month open\u2010label period (period A). Subjects achieving the American College of Rheumatology Pediatric 30 criteria for improvement (defined \u201cresponders\u201d) were randomized to abatacept or placebo (plus MTX) in the 6\u2010month double\u2010blind withdrawal period (period B). HRQOL assessments included 15 Child Health Questionnaire (CHQ) health concepts plus the physical (PhS) and psychosocial summary scores (PsS), pain (100\u2010mm visual analog scale), the Children's Sleep Habits Questionnaire, and a daily activity participation questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 190 subjects from period A and 122 from period B were eligible for analysis. In period A, there were substantial improvements across all of the CHQ domains (greatest improvement was in pain\/discomfort) and the PhS (8.3 units) and PsS (4.3 units) with abatacept. At the end of period B, abatacept\u2010treated subjects had greater improvements versus placebo in all domains (except behavior) and both summary scores. Similar improvement patterns were seen with pain and sleep. For participation in daily activities, an additional 2.6 school days\/month and 2.3 parents' usual activity days\/month were gained in period A responders with abatacept, and further gains were made in period B (1.9 versus 0.9 [<jats:italic>P<\/jats:italic> = 0.033] and 0.2 versus \u22121.3 [<jats:italic>P<\/jats:italic> = 0.109] school days\/month and parents' usual activity days\/month, respectively, in abatacept\u2010 versus placebo\u2010treated subjects).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Improvements in HRQOL were observed with abatacept, providing real\u2010life tangible benefits to children with JIA and their parents\/caregivers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.20283","type":"journal-article","created":{"date-parts":[[2010,7,6]],"date-time":"2010-07-06T15:35:47Z","timestamp":1278430547000},"page":"1542-1551","source":"Crossref","is-referenced-by-count":68,"title":["Abatacept improves health\u2010related quality of life, pain, 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