{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:51:16Z","timestamp":1791143476795,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T00:00:00Z","timestamp":1280188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the efficacy and tolerance of azathioprine in severe uveitis related to Beh\u00e7et's disease (BD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reported 157 consecutive patients with severe uveitis (active posterior uveitis or panuveitis) fulfilling the international criteria for BD and treated with corticosteroids (0.5\u20131 mg\/kg\/day) and azathioprine (2.5 mg\/kg\/day). Long\u2010term outcome and factors associated with complete remission were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean \u00b1 SD age at diagnosis was 29.9 \u00b1 10.1 years, with 71.3% men. At baseline, 59 patients (37.6%) had loss of useful vision, 54 (34.4%) had retinal vasculitis, 66 (42.0%) had panuveitis, and 132 (84.1%) had bilateral uveitis. Following azathioprine therapy, 81 patients (51.6%) were complete responders, 65 (41.4%) were partial responders, and 11 (7%) were nonresponders. The visual acuity significantly improved (<jats:italic>P<\/jats:italic> &lt; 0.001), and a significant decrease in the mean oral prednisone dosage (55.3 to 10.5 mg\/day; <jats:italic>P<\/jats:italic> &lt; 0.001) was observed after therapy. Patients with retinal vasculitis (odds ratio [OR] 0.45 [95% confidence interval (95% CI) 0.2\u20130.9], <jats:italic>P<\/jats:italic> = 0.02) and severe visual loss (OR 0.28 [95% CI 0.2\u20130.7], <jats:italic>P<\/jats:italic> &lt; 0.0001) at diagnosis were less likely to be complete responders. Azathioprine was well tolerated, with only 3 withdrawals due to hepatotoxic effects (n = 2) and bacterial septicemia (n = 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Azathioprine represents an effective and safe therapy in patients with severe uveitis of BD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.20308","type":"journal-article","created":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T14:45:16Z","timestamp":1280241916000},"page":"1733-1738","source":"Crossref","is-referenced-by-count":82,"title":["Azathioprine in severe uveitis of Beh\u00e7et's disease"],"prefix":"10.1002","volume":"62","author":[{"given":"D.","family":"Saadoun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wechsler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Terrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Hajage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Le Thi Huong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Resche\u2010Rigon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Cassoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Le Hoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Amoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bodaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Cacoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411707"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200101000-00004"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.03.022"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200301000-00006"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.080432"},{"key":"e_1_2_6_7_2","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","volume":"335","author":"International Study Group for Beh\u00e7et's Disease","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20176"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21231"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.08.038"},{"key":"e_1_2_6_12_2","first-page":"1633","article-title":"Interferon\u2010a (IFN\u2010a) application versus tumor necrosis factor\u2010a antagonism for ocular Beh\u00e7et's disease: focusing more on IFN","volume":"32","author":"Kotter I","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_6_13_2","first-page":"343","article-title":"Ocular prognosis in Beh\u00e7et's disease","volume":"15","author":"Cochereau\u2010Massin I","year":"1992","journal-title":"J Fr Ophtalmol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199002013220501"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400425"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273940802204519"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.6133"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-006-9006-9"},{"key":"e_1_2_6_19_2","first-page":"928","article-title":"Interferon \u03b1 combined with azathioprine for the uveitis of Beh\u00e7et's disease: an open study","volume":"4","author":"Hamuryudan V","year":"2002","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.025882"},{"key":"e_1_2_6_21_2","first-page":"S14","article-title":"Infliximab in refractory uveitis due to Beh\u00e7et's disease","volume":"22","author":"Wechsler B","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-5-200403020-00025"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1076\/ocii.8.4.293.6453"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.080432"}],"container-title":["Arthritis Care &amp; 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