{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:49:48Z","timestamp":1759452588150,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T00:00:00Z","timestamp":1291075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the natural history and clinical significance of forefoot bursae over a 12\u2010month period in patients with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with RA (n = 149) attending rheumatology outpatient clinics were assessed at baseline. A total of 120 participants, mean \u00b1 SD age 60.7 \u00b1 12.1 years and mean \u00b1 SD disease duration 12.99 \u00b1 10.4 years, completed the 12\u2010month followup (98 women, 22 men, 93 rheumatoid factor positive, 24 rheumatoid factor negative, and 3 unknown). Musculoskeletal ultrasound (US) was used to identify forefoot bursae in all of the participants. Clinical markers of disease activity (well\u2010being visual analog scale [VAS], erythrocyte sedimentation rate [ESR], C\u2010reactive protein [CRP] level, and Disease Activity Score in 28 joints [DAS28]) and foot symptoms on the Leeds Foot Impact Scale (LFIS) Questionnaire were recorded on both occasions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Presence of US\u2010detectable forefoot bursae was identified in 93.3% of returnee (n = 120) participants (individual mean 3.7, range 0\u201311) at baseline. Significant associations were identified between bursae presence and patient\u2010reported foot impact for impairment\/footwear (LFIS<jats:sub>IF<\/jats:sub>; baseline: r = 0.226, <jats:italic>P<\/jats:italic> = 0.013 and 12 months: r = 0.236, <jats:italic>P<\/jats:italic> = 0.009) and activity limitation\/participation restriction (LFIS<jats:sub>AP<\/jats:sub>; baseline: r = 0.254, <jats:italic>P<\/jats:italic> = 0.005 and 12 months: r = 0.235, <jats:italic>P<\/jats:italic> = 0.010). After 12 months, 42.5% of participants had an increase in the number of US\u2010detectable forefoot bursae and 45% of participants had a decrease. Changes in bursae number significantly correlated with changes in LFIS<jats:sub>IF<\/jats:sub> (r = 0.216, <jats:italic>P<\/jats:italic> = 0.018) and LFIS<jats:sub>AP<\/jats:sub> (r = 0.193, <jats:italic>P<\/jats:italic> = 0.036). No significant associations were identified between changes in bursae and changes in global well\u2010being VAS, ESR, CRP level, or DAS28.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of this study suggest that forefoot bursae may regress or hypertrophy over time in patients with RA, and that these changes may be associated with self\u2010reported foot impairment and activity restriction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.20326","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T23:19:06Z","timestamp":1282173546000},"page":"1756-1762","source":"Crossref","is-referenced-by-count":24,"title":["Assessment of the natural history of forefoot bursae using ultrasonography in patients with rheumatoid arthritis: A twelve\u2010month investigation"],"prefix":"10.1002","volume":"62","author":[{"given":"Catherine 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