{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:11:05Z","timestamp":1792030265803,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T00:00:00Z","timestamp":1317081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Recent evidence suggests that anti\u2010Ro\/SSA antibodies, strongly associated with the development of congenital heart block, may also be arrhythmogenic for the adult heart. In fact, anti\u2010Ro\/SSA\u2013positive patients with connective tissue disease (CTD) frequently display corrected QT (QTc) prolongation associated with an increase in ventricular arrhythmias. However, QTc prolongation prevalence markedly differs throughout the studies (10\u201360%), but the reason why is not yet clear. The aim of this study was to evaluate whether anti\u2010Ro\/SSA\u2013associated QTc prolongation in adult patients with CTD is related to antibody level and specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010nine adult patients with CTD underwent a resting 12\u2010lead electrocardiogram recording to measure QTc interval, and a venous withdrawal to determine anti\u2010Ro\/SSA antibody level and specificity (anti\u2013Ro\/SSA 52 kd and anti\u2013Ro\/SSA 60 kd) by immunoenzymatic methods and Western blotting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our population, a direct correlation was demonstrated between anti\u2013Ro\/SSA 52\u2010kd level and QTc duration (r = 0.38, <jats:italic>P<\/jats:italic> = 0.007), patients with a prolonged QTc had higher levels of anti\u2013Ro\/SSA 52 kd with respect to those with a normal QTc (<jats:italic>P<\/jats:italic> = 0.003), and patients with a moderate to high level (\u226550 units\/ml) of anti\u2013Ro\/SSA 52 kd showed a longer QTc interval (<jats:italic>P<\/jats:italic> = 0.008) and a higher QTc prolongation prevalence (<jats:italic>P<\/jats:italic> = 0.008) than those with a low positive\/negative level (&lt;50 units\/ml). On the contrary, no association was found between QTc and anti\u2013Ro\/SSA 60\u2010kd level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In anti\u2010Ro\/SSA\u2013positive adult patients with CTD, the occurrence of QTc prolongation seems strictly dependent on the anti\u2013Ro\/SSA 52\u2010kd level. This finding, possibly explaining the different QTc prolongation prevalence reported, strengthens the hypothesis that an extremely specific autoimmune cross\u2010reaction is responsible for the anti\u2010Ro\/SSA\u2013dependent interference on ventricular repolarization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.20540","type":"journal-article","created":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T15:13:39Z","timestamp":1310051619000},"page":"1463-1470","source":"Crossref","is-referenced-by-count":51,"title":["Anti\u2010Ro\/SSA\u2013associated corrected QT interval prolongation in adults: The role of antibody level and specificity"],"prefix":"10.1002","volume":"63","author":[{"given":"Pietro Enea","family":"Lazzerini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Leopoldo","family":"Capecchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Acampa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Morozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bellisai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Romana","family":"Bacarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Dragoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Fineschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Simpatico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Galeazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Laghi\u2010Pasini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2004.11.003"},{"key":"e_1_2_7_3_2","first-page":"81","volume-title":"Progress in cardiac arrhythmias research","author":"Lazzerini PE","year":"2008"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930400022954"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.03.002"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-007-0686-8"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20130"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20845"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20470"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2010.02428.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.04.048"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.037"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.042"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1313.036"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.014"},{"key":"e_1_2_7_16_2","first-page":"366","article-title":"Absence of conduction defects in the electrocardiograms of mothers with children with congenital complete heart block","volume":"28","author":"Gordon PA","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb07010.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2009.089656"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2010.02439.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.002425"},{"key":"e_1_2_7_21_2","first-page":"145","article-title":"Extraordinary antigenicity of the human Ro52 autoantigen","volume":"2","author":"Burbelo PD","year":"2010","journal-title":"Am J Transl Res"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-008-0028-1"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep145"}],"container-title":["Arthritis Care &amp; 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