{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:47:42Z","timestamp":1790948862001,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T00:00:00Z","timestamp":1317081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate balance, gait, falls, and fear of falling in patients with the hypermobility type of Ehlers\u2010Danlos syndrome (EDS\u2010HT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010two women with EDS\u2010HT and 22 sex\u2010 and age\u2010matched healthy control subjects participated in the study. Each subject performed the modified Clinical Test of Sensory Interaction on Balance (mCTSIB) and the Tandem Stance test (TS) on an AccuGait force platform to assess balance by center of pressure\u2013based postural sway measures. The GAITRite walkway system was used to record spatial\u2013temporal gait variables during 3 walking conditions (single task, cognitive task, and functional task). Data about fall frequency and circumstances were collected by retrospective recall, and fear of falling was assessed by the modified Falls Efficacy Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy subjects, EDS\u2010HT subjects showed significantly impaired balance, reflected by increased sway velocity, mediolateral and anteroposterior sway excursion, and sway area during mCTSIB and TS. Gait velocity, step length, and stride length were significantly smaller during all walking conditions, and a significant dual\u2010task\u2013related decrement was found for gait velocity, step and stride length, and cadence in the EDS\u2010HT subjects compared to the control group. Ninety\u2010five percent of the patients fell during the past year, and some fear of falling was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this study is the first to establish that EDS\u2010HT is associated with balance and gait impairments, increased fall frequency, and poorer balance confidence, implying a decrease in the safety of standing in everyday life situations. Whether these deficits can be improved by appropriate exercise programs needs to be addressed in future research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.20557","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T12:25:14Z","timestamp":1311683114000},"page":"1432-1439","source":"Crossref","is-referenced-by-count":91,"title":["Balance, gait, falls, and fear of falling in women with the hypermobility type of Ehlers\u2010Danlos syndrome"],"prefix":"10.1002","volume":"63","author":[{"given":"Lies","family":"Rombaut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fransiska","family":"Malfait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"De 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