{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:42:37Z","timestamp":1760888557045,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T00:00:00Z","timestamp":1319673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore whether the risk of incident tibiofemoral (TF) osteoarthritis (OA) in the radiographically normal contralateral knee of overweight\/obese women with unilateral knee OA is mediated by malalignment and\/or preceded by increased turnover of subchondral bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data of post hoc analyses from a randomized controlled trial. Cross\u2010sectional analyses evaluated the baseline association between frontal plane alignment and bone turnover in the medial TF compartment in 78 radiographically normal contralateral knees. Longitudinal analyses ascertained whether incident radiographic OA (TF osteophyte formation within 30 months) was associated with malalignment and\/or increased bone turnover at baseline. Alignment subcategories (varus\/neutral\/valgus) were based on the anatomic axis angle. <jats:sup>99m<\/jats:sup>Tc\u2013methylene diphosphonate uptake in a late\u2010phase bone scan was quantified in regions of interest in the medial tibia (MT) and medial femur (MF) and adjusted for uptake in a reference segment of the ipsilateral tibial shaft (TS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MF and MT uptake in varus contralateral knees was 50\u201355% greater than in the TS. Adjusted MT uptake in varus contralateral knees was significantly greater than that in neutral and valgus contralateral knees (mean 1.55 versus 1.38 and 1.43, respectively; <jats:italic>P<\/jats:italic> &lt; 0.05). Among 69 contralateral knees followed longitudinally, 22 (32%) developed TF OA. Varus angulation was associated with a marginally significant increase in the odds of incident OA (adjusted odds ratio 3.98, <jats:italic>P<\/jats:italic> = 0.067).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While the small sample size limited our ability to detect statistically significant risk factors, these data suggest that the risk of developing bilateral TF OA in overweight\/obese women may be mediated by varus malalignment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.20574","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T02:22:53Z","timestamp":1314843773000},"page":"1528-1534","source":"Crossref","is-referenced-by-count":15,"title":["Malalignment and subchondral bone turnover in contralateral knees of overweight\/obese women with unilateral osteoarthritis: Implications for bilateral disease"],"prefix":"10.1002","volume":"63","author":[{"given":"Steven A.","family":"Mazzuca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen A.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Chakr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.058347"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2008.08.009"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2009.06.001"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115334"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-1-18"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.085530"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20726"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24337"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00081-X"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.03.017"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(98)00028-1"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.094722"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.8.557"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10630"},{"key":"e_1_2_7_16_2","first-page":"329","article-title":"Bone scintigraphy is not a better predictor of progression of knee osteoarthritis than Kellgren and Lawrence grade","volume":"31","author":"Mazzuca SA","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_17_2","first-page":"1540","article-title":"Severity of joint pain and Kellgren and Lawrence grade at baseline are better predictors of joint space narrowing than bone scintigraphy in patients with knee osteoarthritis","volume":"32","author":"Mazzuca SA","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0030-5898(20)31924-6","article-title":"Dynamics of knee alignment","volume":"25","author":"Andriacchi TP","year":"1994","journal-title":"Orthop Clin North Am"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21122"},{"key":"e_1_2_7_20_2","first-page":"21","volume-title":"Anthropometric reference data and prevalence of overweight: United States, 1976\u201080","author":"Najjar MF","year":"1987"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.11.872"},{"key":"e_1_2_7_23_2","first-page":"3","article-title":"Atlas of individual radiographic features in osteoarthritis","volume":"3","author":"Altman RD","year":"1995","journal-title":"Osteoarthritis Cartilage"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21100"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198769050-00016"},{"key":"e_1_2_7_26_2","first-page":"1833","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy N","year":"1988","journal-title":"J Rheumatol"},{"volume-title":"SAS 9.2","year":"2009","key":"e_1_2_7_27_2"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.03.018"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090114"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-61731-7"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20657"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-7-535"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.8.622"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.131.3404.897"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780231114"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092270405"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789x.2001.00034.x"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200704000-00012"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22515"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197003000-00035"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453677308988675"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.055905"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.20574","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.20574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:09:44Z","timestamp":1759424984000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.20574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,27]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1002\/acr.20574"],"URL":"https:\/\/doi.org\/10.1002\/acr.20574","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"type":"print","value":"2151-464X"},{"type":"electronic","value":"2151-4658"}],"subject":[],"published":{"date-parts":[[2011,10,27]]}}}