{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:48:15Z","timestamp":1791568095861,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T00:00:00Z","timestamp":1319673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the contribution of routine viral screening tests in patients with early rheumatoid arthritis (RA) or a potential for progressing to RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight hundred thirteen patients with swelling of at least 2 joints for at least 6 weeks and a symptom duration of less than 6 months in the ESPOIR cohort were screened for parvovirus B19 (IgG and IgM anti\u2013parvovirus B19 antibodies), hepatitis B virus (HBV; hepatitis B surface antigen), hepatitis C virus (HCV; anti\u2010HCV antibodies), and human immunodeficiency virus (HIV; anti\u2013HIV\u20101 and \u20102 antibodies).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Parvovirus B19 testing was performed in 806 patients and showed longstanding immunity in 574 (71.2%) and no antibodies in 223 (27.7%). Among the 9 remaining patients (7 IgG positive\/IgM positive, 1 IgG negative\/IgM positive, and 1 IgG indeterminate\/IgM positive), only 2 (0.25%; 95% confidence interval [95% CI] 0\u20130.99%) had a positive polymerase chain reaction test for parvovirus B19; these patients (women ages 34 and 40 years) had no extraarticular signs. HIV seroprevalence was 0.12% (n = 1 of 813; 95% CI 0.01\u20130.8%) and HCV seroprevalence was 0.86% (n = 7 of 808, 95% CI 0.38\u20131.86%). HCV\u2010related arthritis was diagnosed in 4 patients (0.5%). HCV\u2010seropositive patients had significantly higher transaminase levels than the other patients (<jats:italic>P<\/jats:italic> = 0.001), with no significant differences for the other laboratory data. HBV seroprevalence was 0.12% (n = 1 of 808; 95% CI 0.01\u20130.8%); the positive HBV status was known before study inclusion, and the patient had no diagnosis of HBV\u2010related arthritis. Finally, routine viral testing identified 2 patients with parvovirus B19 infection and 3 with HBV infection (0.6%; 95% CI 0.2\u20131.5%). Cost was \u20ac85.05 per patient (total \u20ac68,720).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Routine serologic testing did not contribute substantially to the diagnosis in this context.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.20576","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T22:35:27Z","timestamp":1317162927000},"page":"1565-1570","source":"Crossref","is-referenced-by-count":39,"title":["Is routine viral screening useful in patients with recent\u2010onset polyarthritis of a duration of at least 6 weeks? Results from a nationwide longitudinal prospective cohort study"],"prefix":"10.1002","volume":"63","author":[{"given":"Sophie","family":"Varache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Narbonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Jousse\u2010Joulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Guennoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Pierre","family":"Daur\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Devauchelle\u2010Pensec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Saraux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,27]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328333b9f5"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2480"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2006.08.007"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.12.005"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081308"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2007.06.001"},{"key":"e_1_2_8_8_2","unstructured":"Institut de Veille Sanitaire Rapport. 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