{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:24:23Z","timestamp":1791037463095,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T00:00:00Z","timestamp":1325030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2012,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To examine the relationship between knee osteoarthritis (OA) and muscle parameters in a biracial cohort of older adults.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Participants in the Health, Aging and Body Composition Study (n = 858) were included in this cross\u2010sectional analysis. Computed tomography was used to measure muscle area, and quadriceps strength was measured isokinetically. Muscle quality (specific torque) was defined as strength per unit of muscle area for both the entire thigh and quadriceps. Knee OA was assessed based on radiographic features and knee pain. We compared muscle parameters between those with and without radiographic knee OA (+RKOA group and \u2212RKOA group, respectively) and among 4 groups defined by +RKOA and \u2212RKOA with and without pain.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean \u00b1 SD age was 73.5 \u00b1 2.9 years and the mean \u00b1 SD body mass index (BMI) was 27.9 \u00b1 4.8 kg\/m\n 2<\/jats:sup>\n . Fifty\u2010eight percent of participants were women and 44% were African American. Compared to the \u2212RKOA participants, +RKOA participants had a higher BMI (30.2 versus 26.8 kg\/m\n 2<\/jats:sup>\n ), larger thigh muscles (117.9 versus 108.9 cm\n 2<\/jats:sup>\n ), and a greater amount of intermuscular fat (12.5 versus 9.9 cm\n 2<\/jats:sup>\n ; all\n P<\/jats:italic>\n < 0.0001). In adjusted models, the +RKOA participants had significantly lower specific torque (\n P<\/jats:italic>\n < 0.001), indicating poorer muscle quality, than \u2212RKOA participants, but there was no difference between groups in quadriceps specific torque. The +RKOA without pain (\n P<\/jats:italic>\n < 0.05) and the +RKOA with pain (\n P<\/jats:italic>\n < 0.001) participants had lower specific torque compared to the \u2212RKOA without pain group. There were no significant differences in quadriceps specific torque among groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Muscle quality was significantly poorer in participants with RKOA regardless of pain status. Future studies should address how lifestyle interventions might affect muscle quality and progression of knee OA.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acr.20588","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T01:30:13Z","timestamp":1314840613000},"page":"15-21","source":"Crossref","is-referenced-by-count":94,"title":["Muscle strength, mass, and quality in older men and women with knee osteoarthritis"],"prefix":"10.1002","volume":"64","author":[{"given":"Molly B.","family":"Conroy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Kent","family":"Kwoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eswar","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Nevitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Boudreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D.","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hepei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara B.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret H.","family":"Goodpaster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Health ABC Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.84.3.351"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23176"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.2.91"},{"key":"e_1_2_6_5_2","volume-title":"International database, table 094: midyear population, by age and sex","author":"US Census Bureau"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1508"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-2-199707150-00011"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-2-199707150-00001"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.12.013"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.028746"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199811)41:11<1951::AID-ART9>3.0.CO;2-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0889-857X(21)00334-3","article-title":"The course of osteoarthritis and factors that affect it","volume":"19","author":"Felson DT","year":"1993","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114878"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.2.644"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-8-200304150-00006"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.1.104"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.6.2157"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/45.1.7"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.6.2157"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(78)90058-9"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52154.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.007583"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24541"}],"container-title":["Arthritis Care & Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.20588","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.20588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:44:39Z","timestamp":1759427079000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.20588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,28]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1002\/acr.20588"],"URL":"https:\/\/doi.org\/10.1002\/acr.20588","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,28]]}}}