{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:52:08Z","timestamp":1791139928196,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,11,29]],"date-time":"2011-11-29T00:00:00Z","timestamp":1322524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Chronic inflammatory diseases in adults have been associated with increased cardiovascular risk and impaired vascular function. We aimed to assess the presence of early vascular dysfunction in patients with juvenile idiopathic arthritis (JIA) and investigate the role of inherent inflammatory process of JIA in vascular health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty patients with JIA (age range 7\u201318 years) were compared to 33 age\u2010 and sex\u2010matched controls. Endothelial function (brachial artery flow\u2010mediated dilation [FMD]), carotid intima\u2010media thickness (IMT), and arterial stiffness were examined. Endothelial inflammation was assessed by intercellular adhesion molecule 1 (ICAM\u20101) and P\u2010selectin measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with JIA showed decreased FMD compared to controls (<jats:italic>P<\/jats:italic> = 0.001), independent of age (<jats:italic>P<\/jats:italic> = 0.9 among age subgroups). Baseline differences in erythrocyte sedimentation rate, ICAM\u20101, and glucose between the 2 groups accounted for the difference in FMD. The presence of systemic JIA was associated with greater IMT compared to patients with oligoarticular disease, polyarticular disease, or controls (<jats:italic>P<\/jats:italic> = 0.014, <jats:italic>P<\/jats:italic> = 0.069, and <jats:italic>P<\/jats:italic> = 0.046, respectively). The difference in IMT between systemic versus oligoarticular\/polyarticular JIA was attributed to the following risk factors: age, body mass index, blood pressure, disease activity, and corticosteroids use. There were no differences in arterial stiffness indices between JIA patients and controls or between patients with systemic versus nonsystemic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Endothelial function is impaired in patients with JIA at a very young age, while IMT is increased only in the presence of systemic JIA. Vascular dysfunction may be partly attributed to the effects of disease\u2010related characteristics (inflammation, disease activity, and medications).<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.20613","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T00:31:49Z","timestamp":1315528309000},"page":"1736-1744","source":"Crossref","is-referenced-by-count":59,"title":["Changes in vascular function and structure in juvenile idiopathic arthritis"],"prefix":"10.1002","volume":"63","author":[{"given":"Antonios P.","family":"Vlahos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Theocharis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Bechlioulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina 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