{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:43:47Z","timestamp":1791582227262,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T00:00:00Z","timestamp":1343347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of a supervised exercise training program on health parameters, physical capacity, and health\u2010related quality of life in patients with mild and chronic juvenile dermatomyositis (DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective longitudinal study following 10 children with mild and chronic juvenile DM (disease duration &gt;1 year). The exercise program consisted of twice\u2010a\u2010week aerobic and resistance training. At baseline and after the 12\u2010week intervention, we assessed muscle strength and function, aerobic conditioning, body composition, juvenile DM scores, and health\u2010related quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Child self\u2010report and parent proxy\u2010report Pediatric Quality of Life Inventory scores were improved after the intervention (\u221240.3%; <jats:italic>P<\/jats:italic> = 0.001 and \u221248.2%; <jats:italic>P<\/jats:italic> = 0.049, respectively). Importantly, after exercise, the Disease Activity Score was reduced (\u221226.9%; <jats:italic>P<\/jats:italic> = 0.026) and the Childhood Muscle Assessment Scale was improved (+2.5%; <jats:italic>P<\/jats:italic> = 0.009), whereas the Manual Muscle Test presented a trend toward statistical significance (+2.2%; <jats:italic>P<\/jats:italic> = 0.081). The peak oxygen consumption and time\u2010to\u2010exhaustion were increased by 13.3% (<jats:italic>P<\/jats:italic> = 0.001) and 18.2% (<jats:italic>P<\/jats:italic> = 0.003), respectively, whereas resting heart rate was decreased by 14.7% (<jats:italic>P<\/jats:italic> = 0.006), indicating important cardiovascular adaptations to the exercise program. Upper and lower extremity muscle strength and muscle function were also significantly improved after the exercise training (<jats:italic>P<\/jats:italic> &lt; 0.05). Both the whole\u2010body and the lumbar spine bone mineral apparent density were significantly increased after training (1.44%; <jats:italic>P<\/jats:italic> = 0.044 and 2.85%; <jats:italic>P<\/jats:italic> = 0.008, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We showed for the first time that a 12\u2010week supervised exercise program is safe and can improve muscle strength and function, aerobic conditioning, bone mass, disease activity, and health\u2010related quality of life in patients with active and nonactive mild and chronic juvenile DM with near normal physical function and quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.21684","type":"journal-article","created":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T15:51:16Z","timestamp":1334332276000},"page":"1186-1194","source":"Crossref","is-referenced-by-count":64,"title":["Exercise training in juvenile 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