{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:53:51Z","timestamp":1784141631155,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T00:00:00Z","timestamp":1356566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if a dose\u2010response relationship exists between percentage changes in body weight in persons with symptomatic knee osteoarthritis (OA) and self\u2010reported pain and function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from persons in the Osteoarthritis Initiative (OAI) and the Multicenter Osteoarthritis (MOST) study data sets (n = 1,410) with symptomatic function\u2010limiting knee OA were studied. For the OAI, we used baseline and 3\u2010year followup data, while for the MOST study, baseline and 30\u2010month data were used. Key outcome variables were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function and pain change scores. In addition to covariates, the predictor variable of interest was the extent of weight change over the study period divided into 5 categories representing different percentages of body weight change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant dose\u2010response relationship (<jats:italic>P<\/jats:italic> &lt; 0.003) was found between the extent of percentage change in body weight and the extent of change in WOMAC physical function and WOMAC pain scores. For example, persons who gained \u226510% of body weight had WOMAC physical function score changes of \u22125.4 (95% confidence interval \u22128.7, \u22122.00) points, indicating worsening physical function relative to the reference group of persons with weight changes between &lt;5% weight gain and &lt;5% weight reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest a dose\u2010response relationship exists between changes in body weight and corresponding changes in pain and function. The threshold for this response gradient appears to be body weight shifts of \u226510%. Weight changes of \u226510% have the potential to lead to important changes in pain and function for patient groups as well as individual patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.21692","type":"journal-article","created":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T15:51:36Z","timestamp":1334332296000},"page":"15-22","source":"Crossref","is-referenced-by-count":123,"title":["Body weight changes and corresponding changes in pain and function in persons with symptomatic knee osteoarthritis: A cohort study"],"prefix":"10.1002","volume":"65","author":[{"given":"Daniel L.","family":"Riddle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul 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