{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:11:21Z","timestamp":1791925881074,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,10,27]],"date-time":"2012-10-27T00:00:00Z","timestamp":1351296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether the presence of definite osteophytes (in the absence of joint space narrowing [JSN]) on radiographs is associated with (subregional) increases in cartilage thickness in a within\u2010person, between\u2010knee cross\u2010sectional comparison of participants in the Osteoarthritis Initiative. Based on previous results, the external weight\u2010bearing medial femoral condyle (ecMF) and external weight\u2010bearing lateral femoral condyle (ecLF) subregions were selected as primary end points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Both knees of 61 Osteoarthritis Initiative participants (n = 4,796) displayed definite tibial or femoral marginal osteophytes and no JSN in 1 knee, and no signs of radiographic osteoarthritis (OA) in the contralateral knee; this was confirmed by an expert central reader. In these participants, cartilage thickness was measured in 16 femorotibial subregions of each knee, based on sagittal double\u2010echo steady\u2010state with water excitation magnetic resonance images. Location\u2010specific joint space width from fixed\u2010flexion radiographs was determined using dedicated software. Location\u2010specific associations of osteophytes with cartilage thickness were evaluated using paired <jats:italic>t<\/jats:italic>\u2010tests and mixed\u2010effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 61 participants, 48% had only medial osteophytes, 36% only lateral osteophytes, and 16% bicompartmental osteophytes. The knees with osteophytes had significantly thicker cartilage than contralateral knees without osteophytes in the ecMF (mean \u00b1 SD +71 \u00b1 223 \u03bcmoles, equivalent to an increase of +5.5%; <jats:italic>P<\/jats:italic> = 0.015) and ecLF (mean \u00b1 SD +64 \u00b1 195 \u03bcmoles, +4.1%; <jats:italic>P<\/jats:italic> = 0.013). No significant differences between knees were noted in other subregions or in joint space width. Cartilage thickness in the ecMF and ecLF was significantly associated with tibial osteophytes in the same (medial or lateral) compartment (<jats:italic>P<\/jats:italic> = 0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The knees with early radiographic OA display thicker cartilage than (contralateral) knees without radiographic findings of OA, specifically in the external femoral subregions of compartments with marginal osteophytes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.21719","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T11:32:11Z","timestamp":1336044731000},"page":"1681-1690","source":"Crossref","is-referenced-by-count":68,"title":["Cartilage thickening in early radiographic knee osteoarthritis: A within\u2010person, between\u2010knee comparison"],"prefix":"10.1002","volume":"64","author":[{"given":"Sebastian","family":"Cotofana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Buck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Roemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Duryea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nevitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Eckstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Osteoarthritis Initiative Investigators Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,27]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(96)80016-1"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2004.07.007"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2001.0413"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(03)00162-6"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.1.82"},{"key":"e_1_2_9_7_2","first-page":"428","article-title":"Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection","volume":"18","author":"Adams ME","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2057-y"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200111)44:11<2556::AID-ART436>3.0.CO;2-U"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2072::AID-ART357>3.0.CO;2-3"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20262"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.07.010"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.03.008"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2007.907323"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.06.020"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22207"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2844"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.12.009"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.089904"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-002-0603-z"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22557"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.06.016"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.02.010"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.11.009"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1118\/1.598897"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.11.001"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.039370"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.12.003"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.07.008"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24208"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2009.03.002"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0843"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(99)90846-2"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1999.0256"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.03.005"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.003"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22380"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.09.009"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(99)00144-7"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.214.1.r00ja15259"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-009-0769-8"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.04.018"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2732"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.02.010"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24613"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.02.011"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.099762"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20370"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.21719","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.21719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:41:48Z","timestamp":1759419708000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.21719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,27]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1002\/acr.21719"],"URL":"https:\/\/doi.org\/10.1002\/acr.21719","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,27]]}}}