{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:17:19Z","timestamp":1786976239905,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T00:00:00Z","timestamp":1348790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinical features of dermatomyositis (DM) and clinically amyopathic DM (CADM) patients with the presence of anti\u2013melanoma differentiation\u2013associated gene 5 (anti\u2013MDA\u20105) antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We screened the serum anti\u2013MDA\u20105 antibody levels of 140 patients with various connective tissue diseases (CTDs), including 32 with DM and 32 with CADM, or idiopathic pulmonary fibrosis (IPF). The clinical courses of DM\/CADM patients with a positive expression of anti\u2013MDA\u20105 antibodies were delineated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Anti\u2013MDA\u20105 antibodies were detected at a significantly higher frequency in CADM patients than in DM patients (12 of 32 versus 3 of 32;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.016), but were not detected in patients with other CTDs or IPF and healthy controls. Patients with a positive expression of anti\u2013MDA\u20105 antibodies developed significantly more skin ulcerations (12 of 15 versus 4 of 49;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) and interstitial lung disease (ILD; 15 of 15 versus 31 of 49 [\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003]) than those without anti\u2013MDA\u20105 antibodies. High\u2010resolution computed tomography scores of the MDA\u20105\u2013positive subset were increased compared with the MDA\u20105\u2013negative group (mean \u00b1 SD 117.7 \u00b1 76.3 versus 54.4 \u00b1 50.7;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004), and the scores correlated well with anti\u2013MDA\u20105 antibody levels (r\n                      <jats:sup>2<\/jats:sup>\n                      = 0.582,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.029). The respiratory symptoms as well as skin ulcerations were dramatically improved in patients with anti\u2013MDA\u20105 antibody levels &lt;500 units\/ml after treatment, whereas patients with anti\u2013MDA\u20105 antibody levels &gt;500 units\/ml were resistant to the treatment and died of respiratory failure in a short period of time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anti\u2013MDA\u20105 antibody levels closely correlate with the severity of skin ulcerations, ILD, and the prognosis of the disease. Dynamic observation of serum anti\u2013MDA\u20105 antibody levels would be helpful in predicting the course of ILD and facilitating better therapeutic targeting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.21728","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T16:45:06Z","timestamp":1337791506000},"page":"1602-1610","source":"Crossref","is-referenced-by-count":171,"title":["Clinical manifestations of dermatomyositis and clinically amyopathic dermatomyositis patients with positive expression of anti\u2013melanoma differentiation\u2013associated gene 5 antibody"],"prefix":"10.1002","volume":"64","author":[{"given":"Hua","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunli","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruofei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Kuwana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120621"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1152-9"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-1164-z"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10794"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3181b0e910"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep078"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0760"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3282f01a8c"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21023"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24621"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep375"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-223"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.016"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq149"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1993.35"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.ats3-00"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2373041515"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2106157"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2740"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09521.x"},{"key":"e_1_2_7_23_2","first-page":"5.1","volume-title":"Rook's 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