{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:48:47Z","timestamp":1773146927042,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T00:00:00Z","timestamp":1356566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the temporal and dose\u2010related effects of glucocorticoids (GCs) on body mass index (BMI) in children with rheumatic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children initiating GCs for a rheumatic disease (n = 130) were assessed every 3 months for 18 months. BMI, weight, and height Z score trajectories were described according to GC starting dosage in prednisone equivalents: high (\u22651.0 mg\/kg\/day), low (&lt;0.2 mg\/kg\/day to a maximum of 7.5 mg\/day), and moderate (between high and low) dosage. The impact of GC dosing, underlying diagnosis, pubertal status, physical activity, and disease activity on BMI Z scores and on percent body fat was assessed with longitudinal mixed\u2010effects growth curve models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The GC starting dose was high in 59% and moderate in 39% of patients. The peak BMI Z score was +1.29 at 4 months with high\u2010dose GCs and +0.69 at 4.2 months with moderate\u2010dose GCs (<jats:italic>P<\/jats:italic> &lt; 0.001). Overall, 50% (95% confidence interval 41\u201359%) of the children returned to within +0.25 SD of their baseline BMI Z score. Oral GC dose over the preceding 3 months was the most significant determinant of BMI Z score and percent body fat. The proportion of days in receipt of GCs, disease activity, and a diagnosis of systemic\u2010onset juvenile idiopathic arthritis were also associated with BMI Z scores. The correlation between changes in BMI and changes in percent body fat was 0.09.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In children with rheumatic diseases starting moderate and high doses of GCs, BMI Z scores peaked at 4 months, and only half returned to within +0.25 SD of their baseline BMI Z score after 18 months.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.21785","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T09:04:18Z","timestamp":1353402258000},"page":"113-121","source":"Crossref","is-referenced-by-count":18,"title":["Glucocorticoid\u2010related changes in body mass index among children and adolescents with rheumatic diseases"],"prefix":"10.1002","volume":"65","author":[{"given":"Natalie 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