{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:07:24Z","timestamp":1792030044975,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the association between parent\/proxy\u2010 and child\u2010reported fatigue and disease activity in children with polyarticular, extended oligoarticular, and persistent oligoarticular juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled a cross\u2010sectional cohort of 309 children recruited from the Seattle Children's Hospital rheumatology clinic from 2009\u20132011. Parents and children completed the PedsQL Multidimensional Fatigue Scales. The parent\/proxy, child, and\/or physician provided additional disease activity data at each clinic visit, including active joint count, pain, and the Childhood Health Assessment Questionnaire (C\u2010HAQ). Disease activity was dichotomized as active or inactive using the American College of Rheumatology provisional criteria for clinically inactive disease. The Juvenile Arthritis Disease Activity Score (JADAS) was also calculated. Linear regression was used to examine the associations between fatigue and disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Associations among fatigue, clinically inactive disease, and the JADAS were not statistically significant after controlling for pain. In the multivariable models of fatigue, the C\u2010HAQ and parent\/child\u2010reported disease activity were significantly associated with fatigue; however, only the C\u2010HAQ remained significantly associated after adjustment for pain. The C\u2010HAQ and parent\/child\u2010reported disease activity explained 17% and 30% of the variance in fatigue for the parent\/proxy\u2010 and child\u2010reported multivariable models, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this cohort, functional ability, as measured by the C\u2010HAQ, was significantly associated with fatigue. Child\u2010 and parent\/proxy\u2010reported pain were important confounders of the relationship between fatigue and disease activity. Routinely incorporating pain and fatigue into interventional and observational trials of JIA will enable better delineation of the relationships between these variables.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.21801","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T09:04:09Z","timestamp":1353402249000},"page":"391-397","source":"Crossref","is-referenced-by-count":35,"title":["Disease activity and fatigue in juvenile idiopathic arthritis"],"prefix":"10.1002","volume":"65","author":[{"given":"Sarah","family":"Ringold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa M.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/17477160903111706"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20609"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.01.022"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.2.252"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsm121"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10095"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22473"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24477"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.091454"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep287"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep367"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1887-y"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep144"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker256"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10986"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20952"},{"key":"e_1_2_7_18_2","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_19_2","first-page":"2494","article-title":"The PedsQL multidimensional fatigue scale in pediatric rheumatology: reliability and validity","volume":"31","author":"Varni JW","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20497"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24516"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400703"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371209"},{"key":"e_1_2_7_24_2","first-page":"169","article-title":"Sleep and its relationship to pain, dysfunction, and disease activity in juvenile rheumatoid arthritis","volume":"29","author":"Bloom BJ","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_7_25_2","first-page":"796","article-title":"A case\u2010control sleep study in children with polyarticular juvenile rheumatoid arthritis","volume":"33","author":"Passarelli CM","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20283"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker162"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.21801","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.21801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:16:03Z","timestamp":1759425363000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.21801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,26]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1002\/acr.21801"],"URL":"https:\/\/doi.org\/10.1002\/acr.21801","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,26]]}}}