{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:56:19Z","timestamp":1783137379647,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T00:00:00Z","timestamp":1356566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Hyperuricemia is the most important risk factor for the development of gout; however, not all patients with hyperuricemia develop gout, and patients experiencing a gout attack are not necessarily found to have hyperuricemia. We hypothesized that the interactions between serum uric acid (sUA) and other potential metabolic comorbidities increase the risk of gout development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was conducted to link baseline metabolic profiles from the MJ Health Screening Center to gout outcomes extracted from the Taiwan National Health Insurance database. A Cox proportional hazards model was used to assess the metabolic risks for incident gout stratified by hyperuricemia status (sUA level &gt;7 mg\/dl or not).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a mean followup period of 6.45 years (261,500 person\u2010years), 1,189 patients with clinical gout (899 men, 202 women ages &gt;50 years, and 88 women ages \u226450 years) were identified among the 40,513 examinees. The multivariate adjusted hazard ratios (HRs) of hyperuricemia for gouty arthritis were 5.80 (95% confidence interval [95% CI] 4.93\u20136.81) in men and 4.37 (95% CI 3.38\u20135.66) in women. Hypertriglyceridemia (triglyceride level &gt;150 mg\/dl) was found as an independent risk factor, with HRs of 1.38 (95% CI 1.18\u20131.60) in men with hyperuricemia and 1.40 (95% CI 1.02\u20131.92) in men without hyperuricemia. General obesity (body mass index &gt;27 kg\/m<jats:sup>2<\/jats:sup>) was independently associated with gout in older women, with HRs of 1.72 (95% CI 1.15\u20132.56) in women with hyperuricemia and 2.19 (95% CI 1.47\u20133.26) in women without hyperuricemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>General obesity in women and hypertriglyceridemia in men may potentiate an sUA effect for gout development. Further investigation is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.21824","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T09:04:10Z","timestamp":1353402250000},"page":"133-140","source":"Crossref","is-referenced-by-count":80,"title":["Impact of obesity and hypertriglyceridemia on gout development with or without hyperuricemia: A prospective study"],"prefix":"10.1002","volume":"65","author":[{"given":"Jiunn\u2010Horng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Harn","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Cheng","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Ting","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010Yuan","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin\u2010Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chwen\u2010Tzuei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Lun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20438"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60883-7"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22466"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.076232"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.06.040"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1802-6"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.1.25"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.703389"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27667"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169404"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60952-6"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24164"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-4-200802190-00004"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.22.3.61"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1907"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.7.742"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27338"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2952"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00860.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00851.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.207"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.30291"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.09.013"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1733"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42845"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3071"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60749-6"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.130013"}],"container-title":["Arthritis Care &amp; 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