{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:58:36Z","timestamp":1791025116830,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess quadriceps strength and fatigability by using femoral nerve magnetic stimulation (FNMS) and their relationship to exercise capacity in patients with fibromyalgia syndrome (FMS) and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010two women (11 with FMS, 11 controls) performed a maximal incremental cycling test and a quadriceps fatigue test on 2 separate visits. For quadriceps assessment, we used FNMS during and after maximum voluntary contraction (MVC) to evaluate central and peripheral factors of neuromuscular fatigue. Subjects performed sets of 10 intermittent (5 seconds on\/5 seconds off) isometric contractions starting at 10% MVC, in 10% MVC increments from one set to another until exhaustion. Neuromuscular fatigue was assessed with FNMS after each set.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FMS patients had reduced initial MVC compared to controls (mean \u00b1 SD 102 \u00b1 18 versus 120 \u00b1 24 Nm;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) without significant impairment of voluntary activation (mean \u00b1 SD 93.5% \u00b1 3.0% versus 93.1% \u00b1 3.4%;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.74). During the fatigue task, FMS patients exhibited a greater fall in evoked muscular responses (mean \u00b1 SD \u221226% \u00b1 6% versus \u221216% \u00b1 8% at set 50% MVC;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05), but not in MVC (mean \u00b1 SD \u221224% \u00b1 7% versus \u221219% \u00b1 4% at set 50% MVC;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.12). During the cycling test, FMS patients had lowered maximal exercise capacity and an enhanced rate of perceived exertion (RPE) compared to controls. The percent reduction in evoked muscular responses during the quadriceps fatigue test correlated with maximum oxygen consumption (r = 0.56,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) and RPE at submaximal intensity (r = 0.84,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) during cycling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Greater impairment in muscle contractility is associated with enhanced perception of exertion and reduced maximal exercise capacity in FMS patients. Neuromuscular impairments should be considered as an important factor underlying functional limitations in FMS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.21845","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T09:03:37Z","timestamp":1353402217000},"page":"432-440","source":"Crossref","is-referenced-by-count":52,"title":["Neuromuscular fatigue and exercise capacity in fibromyalgia 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