{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:15:14Z","timestamp":1786976114330,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T00:00:00Z","timestamp":1369872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the metrologic properties of composite disease activity indices in rheumatoid arthritis (RA), utilizing information derived from clinical, gray\u2010scale (GS), and power Doppler (PD) ultrasound examinations, and to assess the classification of patients according to disease activity using such indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This ancillary study utilized data from a multicenter, prospective, randomized, parallel\u2010group study conducted in subjects with moderate RA randomized to receive etanercept and methotrexate (ETN + MTX) or usual care (various disease\u2010modifying antirheumatic drugs [DMARDs]). In multimodal indices, the 28 swollen joint count was either supplemented or replaced by clinically nonswollen joints in which the presence of synovitis was detected either by GS and\/or PD and was calculated according to the Disease Activity Score in 28 joints (DAS28) or the Simplified Disease Activity Index (SDAI). Reliability, external validity, and discriminative capacity were calculated at baseline\/screening by intraclass correlation coefficient, Pearson's correlation, and standardized response mean, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 62 patients (mean \u00b1 SD age 53.8 \u00b1 13.2 years, mean \u00b1 SD disease duration 8.8 \u00b1 7.7 years, mean \u00b1 SD disease activity 4.6 \u00b1 0.5 [DAS28] and 20.9 \u00b1 5.9 [SDAI]) were analyzed, with 32 receiving ETN + MTX and 30 receiving DMARDs. The metrologic properties were at least as good for GS\u2010 and\/or PD\u2010based indices as for their clinical counterparts. Using GS\u2010 and PD\u2010supplemented indices, an additional 67.8% and 32.3% of patients (DAS28\u2010derived and SDAI\u2010derived indices, respectively) could be classified as having high disease activity at the screening visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multimodal indices incorporating ultrasound and clinical data had similar metrologic properties to their clinical counterparts; certain indices allowed for a significantly larger number of patients to be classified to either high or moderate disease activity at the screening visit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.21913","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T17:16:56Z","timestamp":1354641416000},"page":"879-887","source":"Crossref","is-referenced-by-count":30,"title":["Clinical and Ultrasound\u2010Based Composite Disease Activity Indices in Rheumatoid Arthritis: Results From a Multicenter, Randomized Study"],"prefix":"10.1002","volume":"65","author":[{"given":"P.","family":"Mandl","sequence":"first","affiliation":[{"name":"Medical University of Vienna, Vienna, Austria, and National Institute of Rheumatology and Physiotherapy Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. V.","family":"Balint","sequence":"additional","affiliation":[{"name":"National Institute of Rheumatology and Physiotherapy Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Brault","sequence":"additional","affiliation":[{"name":"Pfizer Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Backhaus","sequence":"additional","affiliation":[{"name":"University Hospital Charit\u00e9 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"D'Agostino","sequence":"additional","affiliation":[{"name":"Versailles\u2010Saint Quentin en Yvelines University AP\u2010HP, Ambroise\u2010Par\u00e9 Hospital Boulogne\u2010Billancourt France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Grassi","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Politecnica delle Marche Jesi Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"van der Heijde","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"de Miguel","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Wakefield","sequence":"additional","affiliation":[{"name":"University of Leeds and Chapel Allerton Hospital Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Logeart","sequence":"additional","affiliation":[{"name":"Pfizer Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dougados","sequence":"additional","affiliation":[{"name":"Paris\u2010Descartes University UPRES\u2010EA 4058 AP\u2010HP Cochin Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360601"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.4.219"},{"key":"e_1_2_7_4_1","first-page":"86","article-title":"World Health Organization and International League of Associations for Rheumatology core endpoints for symptom modifying antirheumatic drugs in rheumatoid arthritis clinical trials","volume":"41","author":"Boers M","year":"1994","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.49.11.916"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg072"},{"key":"e_1_2_7_8_1","first-page":"S100","article-title":"The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): a review of their usefulness and validity in rheumatoid arthritis","volume":"23","author":"Aletaha D","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199906)42:6<1232::AID-ANR21>3.0.CO;2-3"},{"key":"e_1_2_7_10_1","first-page":"966","article-title":"Ultrasonography is superior to clinical examination in the detection and localization of knee joint effusion in rheumatoid arthritis","volume":"30","author":"Kane D","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20333"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20054"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.023929"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20939"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10877"},{"key":"e_1_2_7_16_1","first-page":"562","article-title":"Rheumatoid hand joint synovitis: gray\u2010scale and power Doppler US quantifications following anti\u2010tumor necrosis factor\u2010\u03b1 treatment","volume":"229","author":"Ribbens C","year":"2003","journal-title":"Pilot study. 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