{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:27:46Z","timestamp":1780547266758,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether there is a systemic predisposition to chondrocalcinosis (CC) and to examine the association between CC and osteoarthritis (OA) at distant joints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional study embedded in the Genetics of Osteoarthritis and Lifestyle (GOAL) database (n = 3,170). All GOAL participants have had radiographs of the knees, hands, and pelvis performed. These were scored for OA at the knee, hip, wrist, and metacarpophalangeal (MCP) joints and for CC at the knee, hip, wrist, and symphysis pubis joints and for MCP joint calcification. Systemic predisposition to CC was established using cluster analysis. Odds ratios (95% confidence intervals) were used to examine the association between CC at the index and distant joints, CC and OA at the same joint, and index joint OA and distant joint CC. We adjusted for age, sex, and body mass index, and for distant joint OA, if required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Joints with CC clustered together. This was also observed when participants with OA were excluded from the analysis. CC at each joint was associated with CC at distant joints. Knee and wrist OA but not hip OA was associated with CC at the same joint. MCP joint OA was associated with MCP joint calcification. Knee OA was associated with CC at other joints, and this was independent of OA at the distant joint. There was no association between hip OA and distant joint CC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a systemic predisposition to the apparently sporadic CC. OA is associated with CC at the same joint and at distant joints, except hip OA, which is not associated with hip CC or with CC at distant joints.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.21952","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T11:24:16Z","timestamp":1358421856000},"page":"1052-1058","source":"Crossref","is-referenced-by-count":53,"title":["Evidence of a Systemic Predisposition to Chondrocalcinosis and Association Between Chondrocalcinosis and Osteoarthritis at Distant Joints: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"65","author":[{"given":"A.","family":"Abhishek","sequence":"first","affiliation":[{"name":"University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Doherty","sequence":"additional","affiliation":[{"name":"University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Maciewicz","sequence":"additional","affiliation":[{"name":"AstraZeneca M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Muir","sequence":"additional","affiliation":[{"name":"University of Warwick Warwick UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Doherty","sequence":"additional","affiliation":[{"name":"University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1248","article-title":"The roentgenographic aspects of pseudogout (articular chondrocalcinosis): an analysis of 20 cases","volume":"90","author":"McCarty DJ","year":"1963","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.22.3.142"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/82.4.655"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1969.00300160026005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1967.00300010092017"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780120310"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780130404"},{"key":"e_1_2_7_9_1","first-page":"216","article-title":"Inorganic pyrophosphate concentrations in the synovial fluid of arthritic patients","volume":"78","author":"McCarty DJ","year":"1971","journal-title":"J Lab Clin Med"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160206"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(197605\/06)19:3 <465::AID-ART1780190722>3.0.CO;2-#"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009747709095453"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.2.164"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241210"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.7.571"},{"key":"e_1_2_7_16_1","first-page":"1782","article-title":"Chondrocalcinosis associated with Bartter's syndrome and hypomagnesemia","volume":"21","author":"Munoz\u2010Fernandez S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.12.939"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(92)90019-A"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep081"},{"key":"e_1_2_7_20_1","first-page":"1241","article-title":"The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis: the Framingham Study","volume":"16","author":"Felson DT","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.1.30"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.6.513"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150508"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670200121"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009748409102672"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.4.371"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/122.1.1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2007.00830.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.11.009"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280122"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198971060-00012"},{"key":"e_1_2_7_33_1","first-page":"130","article-title":"Chondrocalcinosis and rapid destruction of the hip","volume":"12","author":"Menkes CJ","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310608"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.7.520"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.Suppl_1.73"},{"key":"e_1_2_7_37_1","first-page":"981","article-title":"Prevalence of chondrocalcinosis in Italian subjects from northeastern Italy: the Pro.V.A (PROgetto Veneto Anziani) study","volume":"27","author":"Ramonda R","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670050090"},{"key":"e_1_2_7_39_1","first-page":"2628","article-title":"Calcium pyrophosphate dihydrate crystal deposition disease of the wrist: trapezioscaphoid joint abnormality","volume":"27","author":"Donich AS","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011183"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21903"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.21952","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.21952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:24:25Z","timestamp":1759415065000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.21952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/acr.21952"],"URL":"https:\/\/doi.org\/10.1002\/acr.21952","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}