{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:19:12Z","timestamp":1793852352903,"version":"4.6.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Nanjing Medical Science and Technique Development Foundation"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81200049"],"award-info":[{"award-number":["81200049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiangsu Province Kejiao Xingwei Program Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the utility of anti\u2013melanoma differentiation\u2013associated gene 5 (anti\u2010MDA5) antibody measurement for predicting a risk for developing rapidly progressive interstitial lung disease (RP\u2010ILD) in patients with polymyositis\/dermatomyositis (PM\/DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010center cohort of 64 consecutive Chinese patients with PM\/DM was examined. Serum anti\u2010MDA5 antibody was measured by enzyme\u2010linked immunosorbent assay. For meta\u2010analysis, we searched PubMed and the Institute for Scientific Information Web of Knowledge for original studies that measured anti\u2010MDA5 antibodies in patients with PM\/DM. We calculated pooled sensitivity, specificity, diagnostic odds ratio (DOR), and the summary receiver operating characteristic (sROC) curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In Chinese patients, anti\u2010MDA5 antibodies were detected in 26 patients with classic DM or clinically amyopathic DM (CADM). Compared with anti\u2010MDA5\u2013negative patients, anti\u2010MDA5\u2013positive patients showed a higher prevalence of RP\u2010ILD (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001). In a total of 233 patients with anti\u2010MDA5 antibody, derived from 16 studies, a higher frequency of CADM was found in Japanese than in non\u2010Japanese patients (74.7% versus 39.2%;\n                      <jats:italic>P<\/jats:italic>\n                      = 1.2 \u00d7 10\n                      <jats:sup>\u22127<\/jats:sup>\n                      ). Meta\u2010analysis revealed that the pooled sensitivity and specificity of anti\u2010MDA5 antibody for RP\u2010ILD was 77% (95% confidence interval [95% CI] 64\u201387%) and 86% (95% CI 79\u201390%), respectively. The pooled DOR was 20.41 (95% CI 9.02\u201346.20) with a favorable area under the sROC curve of 0.89 (95% CI 0.63\u20130.98).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Detection of anti\u2010MDA5 antibody is a valuable tool for identifying DM patients with a high risk for developing RP\u2010ILD, but the distribution of classic DM and CADM in patients with this antibody varies among ethnic groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.21985","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T16:12:14Z","timestamp":1361549534000},"page":"1316-1324","source":"Crossref","is-referenced-by-count":265,"title":["Utility of Anti\u2013Melanoma Differentiation\u2013Associated Gene 5 Antibody Measurement in Identifying Patients With Dermatomyositis and a High Risk for Developing Rapidly Progressive Interstitial Lung Disease: A Review of the Literature and a Meta\u2010Analysis"],"prefix":"10.1002","volume":"65","author":[{"given":"Zhiyong","family":"Chen","sequence":"first","affiliation":[{"name":"Affiliated Drum Tower Hospital, Nanjing University Medical School Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengshu","family":"Cao","sequence":"additional","affiliation":[{"name":"Affiliated Drum Tower Hospital, Nanjing University Medical School Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Nieves","family":"Plana","sequence":"additional","affiliation":[{"name":"Hospital Ramon y Cajal (IRYCIS) and CIBER Epidemiology and Public Health (CIBERESP) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liang","sequence":"additional","affiliation":[{"name":"Affiliated Drum Tower Hospital, Nanjing University Medical School Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hourong","family":"Cai","sequence":"additional","affiliation":[{"name":"Affiliated Drum Tower Hospital, Nanjing University Medical School Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Kuwana","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Sun","sequence":"additional","affiliation":[{"name":"Affiliated Drum Tower Hospital, Nanjing University Medical School Nanjing 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