{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:29:07Z","timestamp":1790281747581,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"A 2006 grant from the French Ministry of Health (Programme Hospitalier de Recherche Clinique)","award":["AOM06133"],"award-info":[{"award-number":["AOM06133"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The European League Against Rheumatism (EULAR) Sj\u00f6gren's Syndrome (SS) Disease Activity Index (ESSDAI) and the EULAR SS Patient\u2010Reported Index (ESSPRI) were recently developed. We aimed to determine whether patients' symptoms differed between patients with and without systemic involvement and if the disease\u2010specific indices correlated with each other in primary SS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen French centers included 395 primary SS patients in the Assessment of Systemic Signs and Evolution in Sj\u00f6gren's Syndrome Cohort. At enrollment, physicians completed the ESSDAI, the SS Disease Activity Index (SSDAI), and the Sj\u00f6gren's Systemic Clinical Activity Index (SCAI), and patients completed the ESSPRI, the Sicca Symptoms Inventory, and the Profile of Fatigue and Discomfort. All scores were compared between patients with and without systemic involvement. Correlations between scores of systemic activity and patients' symptoms were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At enrollment, 120 (30.4%) patients had never experienced systemic complication and 155 (39.2%) patients and 120 (30.4%) patients had, respectively, only past or current systemic manifestations. Past or current systemic patients had higher levels of symptoms, except dryness. The ESSDAI did not correlate with the patient\u2010scored ESSPRI (rho = 0.06, <jats:italic>P<\/jats:italic> = 0.30), whereas the SSDAI and the SCAI, which include subjective items, did correlate (rho = 0.28 and 0.25, respectively; <jats:italic>P<\/jats:italic> &lt; 0.0001 for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Alterations of common patient\u2010reported outcomes are present in all patients with primary SS, including those with systemic complications. However, patient symptoms and systemic complications are 2 different facets of primary SS. Therefore, the use of both systemic and patients' indices, such as the ESSDAI and ESSPRI, are useful. Since these 2 facets weakly overlap, one should identify which of both components is the main target of the treatment to test, when designing clinical trials in primary SS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.21991","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T16:12:32Z","timestamp":1361549552000},"page":"1358-1364","source":"Crossref","is-referenced-by-count":82,"title":["European League Against Rheumatism Sj\u00f6gren's Syndrome Disease Activity Index and European League Against Rheumatism Sj\u00f6gren's Syndrome Patient\u2010Reported Index: A Complete Picture of Primary Sj\u00f6gren's Syndrome Patients"],"prefix":"10.1002","volume":"65","author":[{"given":"R.","family":"Seror","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Sud, AP\u2010HP, H\u00f4pitaux Universitaires Paris\u2010Sud, INSERM U1012, Le Kremlin Bic\u00eatre, France, and AP\u2010HP, H\u00f4tel Dieu Hospital, INSERM U738, University of Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Gottenberg","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaires de Strasbourg, Universit\u00e9 de Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Devauchelle\u2010Pensec","sequence":"additional","affiliation":[{"name":"La Cavale Blanche Teaching Hospital, Brest Occidentale University France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Dubost","sequence":"additional","affiliation":[{"name":"G. Montpied Teaching Hospital, Clermont\u2010Ferrand 1 University Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Le Guern","sequence":"additional","affiliation":[{"name":"Cochin University Hospital, Universit\u00e9 Ren\u00e9\u2010Descartes Paris 5, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Hayem","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 7 Denis Diderot, UFR de M\u00e9decine, AP\u2010HP, H\u00f4pital Bichat Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010L.","family":"Fauchais","sequence":"additional","affiliation":[{"name":"Limoges University Hospital Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Goeb","sequence":"additional","affiliation":[{"name":"CHU d'Amiens Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hachulla","sequence":"additional","affiliation":[{"name":"H\u00f4pital Claude Huriez, Universit\u00e9 de Lille 2 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Y.","family":"Hatron","sequence":"additional","affiliation":[{"name":"H\u00f4pital Claude Huriez, Universit\u00e9 de Lille 2 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Larroche","sequence":"additional","affiliation":[{"name":"H\u00f4pital Avicenne, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Morel","sequence":"additional","affiliation":[{"name":"Lapeyronie Hospital, Universit\u00e9 Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pedriger","sequence":"additional","affiliation":[{"name":"CHU de Rennes, H\u00f4pital Sud Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Puechal","sequence":"additional","affiliation":[{"name":"National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, AP\u2010HP, Paris Descartes University France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rist","sequence":"additional","affiliation":[{"name":"H\u00f4pital de la Source Orl\u00e9ans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Saraux","sequence":"additional","affiliation":[{"name":"La Cavale Blanche Teaching Hospital, Brest Occidentale University France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Sene","sequence":"additional","affiliation":[{"name":"H\u00f4pital Larriboisi\u00e8re, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sibilia","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaires de Strasbourg, Universit\u00e9 de Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Vittecoq","sequence":"additional","affiliation":[{"name":"Inserm 905, Institute for Research and Innovation in 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