{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:16:15Z","timestamp":1786976175437,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We used data from the AutoImmunity and Rituximab (AIR) registry to investigate the safety of surgery for patients with rheumatoid arthritis receiving rituximab (RTX) in routine care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data for patients included in the AIR registry and undergoing surgery during the year following an infusion of RTX were reviewed to describe the frequency of postsurgical complications, compare patients with and without complications, and identify factors associated with complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We examined data for 133 patients with a known date of surgery and at least 1 followup visit, corresponding to 140 procedures, including 94 orthopedic surgeries (67%) and 23 abdominal surgeries (16.5%). The median delay between surgery and the last RTX infusion was 6.4 months (interquartile range 4.3\u20138.7 months), without any difference between patients with and without complications. Nine patients (6.7%) experienced 12 complications (8.5%), including 8 surgical site infections (5.7%) and 1 death due to septic shock. Postoperative complications occurred after 4.3% of abdominal surgeries (1 of 23) and 7.4% of orthopedic surgeries (7 of 95). On univariate analysis, spine surgery was associated with postoperative complications (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.048).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In common practice, the risk of complications may be more important in case of spine surgery, but does not seem to be linked to the time between the last RTX infusion and surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.22056","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T10:42:32Z","timestamp":1370860952000},"page":"1874-1879","source":"Crossref","is-referenced-by-count":43,"title":["Safety of Surgery After Rituximab Therapy in 133 Patients With Rheumatoid Arthritis: Data From the AutoImmunity and Rituximab Registry"],"prefix":"10.1002","volume":"65","author":[{"given":"S.","family":"Godot","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris 06, Inflammation\u2010Immunopathology\u2010Biotherapy Department (I2B), Saint\u2010Antoine Hospital AP\u2010HP Paris"},{"name":"Universit\u00e9 Paris\u2010Sud, H\u00f4pitaux Universitaires Paris\u2010Sud AP\u2010HP, Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010E.","family":"Gottenberg","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence des Maladies Auto\u2010Immunes Rares, F\u00e9d\u00e9ration de M\u00e9dicine Translationelle de Strasbourg, University Hospital of Strasbourg, Strasbourg University Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Paternotte","sequence":"additional","affiliation":[{"name":"University Hospital of Cochin, Paris V University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Pane","sequence":"additional","affiliation":[{"name":"Hotel\u2010Dieu Hospital, Paris V University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Combe","sequence":"additional","affiliation":[{"name":"University Hospital of Lapeyronnie, Montpellier University Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sibilia","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence des Maladies Auto\u2010Immunes Rares, F\u00e9d\u00e9ration de M\u00e9dicine Translationelle de Strasbourg, University Hospital of Strasbourg, Strasbourg University Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.\u2010M.","family":"Flipo","sequence":"additional","affiliation":[{"name":"University Hospital of Lille, University of Lille 2 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Schaeverbeke","sequence":"additional","affiliation":[{"name":"University Hospital of Bordeaux, Bordeaux University Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ravaud","sequence":"additional","affiliation":[{"name":"Hotel\u2010Dieu Hospital, Paris V University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Toussirot","sequence":"additional","affiliation":[{"name":"Clinical Investigation Centre, Biotherapy CBT\u2010506 and University Hospital of Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Berenbaum","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 06, Inflammation\u2010Immunopathology\u2010Biotherapy Department (I2B), Saint\u2010Antoine Hospital AP\u2010HP Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Mariette","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Sud, H\u00f4pitaux Universitaires Paris\u2010Sud, AP\u2010HP Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wendling","sequence":"additional","affiliation":[{"name":"Jean Minjoz Hospital, University of Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sellam","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 06, Inflammation\u2010Immunopathology\u2010Biotherapy Department (I2B), Saint\u2010Antoine Hospital, AP\u2010HP Paris 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