{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:11:03Z","timestamp":1759425063299,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T00:00:00Z","timestamp":1387843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the risk of sick leave and work disability in relation to rheumatic diseases and cardiovascular comorbidities among working individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Employees (n = 12,140) from 45 companies in The Netherlands were prospectively followed up from 1998\u20132008. Questionnaires were used to assess self\u2010reported diseases and employment status. Company records provided individual sick leave data for the first 2.5 years of followup. For a selected sample of the cohort (50%), verification of self\u2010reported diseases was sought through hospital record linkage. Poisson regressions and Cox proportional hazards models were applied to determine the impact of both self\u2010reported and verified diseases on sick leave and work disability, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of days and frequency of sick leave were increased in working individuals with self\u2010reported rheumatic and cardiovascular disease (<jats:italic>P<\/jats:italic> &lt; 0.001), but self\u2010reported cardiovascular comorbidity did not result in more sick leave in those who also self\u2010reported rheumatic disease. Work disability was also increased for both self\u2010reported rheumatic disease and cardiovascular disease (<jats:italic>P<\/jats:italic> &lt; 0.001), but again, no additive effects were found. In the sample verified by clinical review, the frequency or number of days of sick leave was significantly higher in employees with cardiovascular disease (<jats:italic>P<\/jats:italic> &lt; 0.001), inflammatory rheumatic disease (<jats:italic>P<\/jats:italic> &lt; 0.05), and osteoarthritis (<jats:italic>P<\/jats:italic> &lt; 0.05) compared to employees without these diseases. Work disability in the verified sample occurred especially in patients with osteoarthritis (hazard ratio [HR] 12.36 [95% confidence interval (95% CI) 1.59\u201313.66]), fibromyalgia (HR 14.24 [95% CI 2.02\u201316.54]), and cardiovascular disease (HR 4.88 [95% CI 1.70\u201314.01]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rheumatic and cardiovascular diseases increased the risk of sick leave and work disability in a working population, but there was no indication that these effects convey an additive risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22095","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T01:04:25Z","timestamp":1375923865000},"page":"157-163","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Cardiovascular Comorbidities on Work Participation in Rheumatic Diseases: A Prospective Cohort Study Among Working Individuals"],"prefix":"10.1002","volume":"66","author":[{"given":"Lennart R. A.","family":"van der Burg","sequence":"first","affiliation":[{"name":"CAPHRI School for Public Health and Primary Care, Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Boonen","sequence":"additional","affiliation":[{"name":"CAPHRI School for Public Health and Primary Care, Maastricht University, and Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovic G. P. M.","family":"van Amelsvoort","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole W. H.","family":"Jansen","sequence":"additional","affiliation":[{"name":"CAPHRI School for Public Health and Primary Care, Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B. M.","family":"Landew\u00e9","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ijmert","family":"Kant","sequence":"additional","affiliation":[{"name":"CAPHRI School for Public Health and Primary Care, Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101210"},{"key":"e_1_2_7_3_1","first-page":"1248","article-title":"Consequences of rheumatoid arthritis for performance of social roles: a literature review","volume":"34","author":"Geuskens GA","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_7_4_1","first-page":"646","article-title":"Burden of major musculoskeletal conditions","volume":"81","author":"Woolf AD","year":"2003","journal-title":"Bull World Health Organ"},{"key":"e_1_2_7_5_1","first-page":"721","article-title":"Employment across chronic inflammatory rheumatic diseases and comparison with the general population","volume":"32","author":"Mau W","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280701315094"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2669"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24092"},{"key":"e_1_2_7_9_1","first-page":"328","article-title":"Where the immune response meets the vessel wall","volume":"67","author":"Bisoendial RJ","year":"2009","journal-title":"Neth J Med"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.136499"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2010.12.040"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24107"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043430"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-200111000-00008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.60.suppl_1.i32"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3158"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.1025"},{"key":"e_1_2_7_18_1","unstructured":"AkeC CarpenterAL. 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