{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:35:34Z","timestamp":1791858934616,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the degree to which nonmedical factors explain additional variance in parent proxy report and child self\u2010report of health\u2010related quality of life (HRQOL) among newly diagnosed children with juvenile idiopathic arthritis (JIA) after accounting for medical factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Parents (of children ages 2\u201316 years; n = 230) and patients (ages &gt;5 years; n = 180) diagnosed within the previous 6 months completed surveys to assess medical (clinical parameters and functional status) and nonmedical (self\u2010efficacy, coping, barriers to adherence, social support, parental distress, and access to care) factors and HRQOL (Pediatric Quality of Life Inventory Generic Core Scales). Physician\u2010rated global assessment of disease activity, active joint count, and select laboratory variables (rheumatoid factor, antinuclear antibodies, and erythrocyte sedimentation rate) were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nonmedical factors, including self\u2010efficacy, coping with pain, barriers to adherence, social support, and parental distress, explained additional variance in HRQOL total, physical functioning, and psychosocial functioning scales (R\n                      <jats:sup>2<\/jats:sup>\n                      increases of 6%, 1%, and 13% for parent proxy report and 16%, 7%, and 30% for self\u2010report, respectively). Parental distress was uniquely associated with parent proxy\u2010report HRQOL, while child self\u2010efficacy and social support were uniquely associated with self\u2010report HRQOL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nonmedical factors are associated with HRQOL in newly diagnosed patients with JIA after accounting for medical variables, particularly for psychosocial functioning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.22117","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T16:42:49Z","timestamp":1377621769000},"page":"263-269","source":"Crossref","is-referenced-by-count":53,"title":["Determinants of Health\u2010Related Quality of Life in Children Newly Diagnosed With Juvenile Idiopathic Arthritis"],"prefix":"10.1002","volume":"66","author":[{"given":"Michael","family":"Seid","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Huang","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Niehaus","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermine I.","family":"Brunner","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Lovell","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"26","article-title":"The importance of patient\u2010reported outcomes\u2026it's all about the patients","volume":"40","author":"Bren L","year":"2006","journal-title":"FDA Consum"},{"key":"e_1_2_6_3_1","unstructured":"US Department of Health and Human Services Food and Drug Administration. Guidance for industry. Patient\u2010reported outcome measures: use in medical product development to support labeling claims.2006. 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