{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:06:48Z","timestamp":1762430808528,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T00:00:00Z","timestamp":1395792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Our aims were to evaluate the correlation between Juvenile Arthritis Disease Activity Score 27\u2010joint reduced count (JADAS27) with erythrocyte sedimentation rate (ESR) and JADAS27 with C\u2010reactive protein (CRP) scores and to test the agreement of both scores on classifying each disease activity state. We also aimed at verifying the correlation of the 2 scores across juvenile idiopathic arthritis (JIA) categories and to check the correlation between JADAS27\u2010ESR and clinical JADAS27 (JADAS27 without ESR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nationwide cohort of patients with JIA registered in the Portuguese Register, Reuma.pt, was studied. JADAS27\u2010CRP was adapted by replacing ESR with CRP level as the inflammatory marker. JADAS27\u2010CRP was calculated similarly to JADAS27\u2010ESR as the simple linear sum of its 4 components. Pearson's correlations and K statistics were used in the analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 358 children had full data to calculate JADAS27; 65.4% were female and the mean \u00b1 SD disease duration was 11.8 \u00b1 9.1 years. The correlation coefficient between JADAS27\u2010ESR and JADAS27\u2010CRP was 0.967 (<jats:italic>P<\/jats:italic> &lt; 0.0001), although the correlation coefficient between ESR and CRP level was 0.335 (<jats:italic>P<\/jats:italic> &lt; 0.0001). The strong correlation between JADAS27\u2010ESR and JADAS27\u2010CRP was maintained when compared within each JIA category. The agreement between JADAS27\u2010ESR and JADAS27\u2010CRP across the 4 activity states was very good, showing 91.1% of the observations in agreement; K = 0.867 (95% confidence interval 0.824\u20130.91). The correlation between JADAS27 with ESR and JADAS27 without ESR was high (r = 0.97, <jats:italic>P<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>JADAS27 based on CRP level correlated closely with JADAS27\u2010ESR across all disease activity states and JIA categories, indicating that both measures can be used in clinical practice. Moreover, the correlation of JADAS27 with and without ESR was also high, suggesting that this tool might be useful even in the absence of laboratorial measures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.22215","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T16:02:06Z","timestamp":1382371326000},"page":"585-591","source":"Crossref","is-referenced-by-count":18,"title":["Using the Juvenile Arthritis Disease Activity Score Based on Erythrocyte Sedimentation Rate or C\u2010Reactive Protein Level: Results From the Portuguese Register"],"prefix":"10.1002","volume":"66","author":[{"given":"Ana F.","family":"Mour\u00e3o","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular and Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J.","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular and Hospital Garcia de Orta Almada Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Melo\u2010Gomes","sequence":"additional","affiliation":[{"name":"Portuguese Institute of Rheumatology Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando M.","family":"Martins","sequence":"additional","affiliation":[{"name":"Portuguese Society of Rheumatology Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Costa","sequence":"additional","affiliation":[{"name":"ULSAM, Hospital Conde de Bertiandos Ponte de Lima Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipa","family":"Ramos","sequence":"additional","affiliation":[{"name":"Lisbon Academic Medical Centre Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Brito","sequence":"additional","affiliation":[{"name":"Hospital de S\u00e3o Jo\u00e3o and Medical Faculty of O'Porto University Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1tia","family":"Duarte","sequence":"additional","affiliation":[{"name":"Centro Hospitalar de Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Figueira","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Funchal Funchal Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Hospital do Divino Esp\u00edrito Santo S. Miguel, A\u00e7ores Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Furtado","sequence":"additional","affiliation":[{"name":"Hospital do Divino Esp\u00edrito Santo S. Miguel, A\u00e7ores Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Lopes","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarida","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Centro Hospitalar da Cova da Beira Covilh\u00e3 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular and Hospital de Santo Esp\u00edrito Angra do Hero\u00edsmo, Terceira Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Salgado","sequence":"additional","affiliation":[{"name":"Centro Hospitalar de Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Sousa","sequence":"additional","affiliation":[{"name":"Portuguese Institute of Rheumatology Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie C.","family":"Branco","sequence":"additional","affiliation":[{"name":"Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental and CEDOC, New Faculty of Medical Sciences Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o E.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular and Lisbon Academic Medical Center Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Canh\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular and Lisbon Academic Medical Center Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133033"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24516"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400703"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.084459"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081188"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200237"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34373"},{"key":"e_1_2_6_9_1","first-page":"45","article-title":"Reuma.pt: the rheumatic diseases Portuguese register","volume":"36","author":"Canhao H","year":"2011","journal-title":"Acta Reumatol Port"},{"issue":"23","key":"e_1_2_6_10_1","first-page":"S126","article-title":"The Portuguese version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ)","author":"Melo\u2010Gomes JA","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230202"},{"key":"e_1_2_6_12_1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080432"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1740"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202031"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.49.11.916"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.22215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.22215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:52:34Z","timestamp":1759420354000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.22215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,26]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/acr.22215"],"URL":"https:\/\/doi.org\/10.1002\/acr.22215","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"type":"print","value":"2151-464X"},{"type":"electronic","value":"2151-4658"}],"subject":[],"published":{"date-parts":[[2014,3,26]]}}}